Geumsan-gun Public Health Center, Geumsan 32726, Republic of Korea.
Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea.
Nutrients. 2023 Apr 15;15(8):1915. doi: 10.3390/nu15081915.
Studies have reported inconsistent results regarding the relationship between serum vitamin E levels and depressive symptoms. Furthermore, the potential modulating role of age and sex has been underexplored. We conduct an age- and sex-stratified investigation of the association between serological vitamin E status and depressive symptoms in a large nationwide sample. Data from the Korean National Health and Nutrition Examination Survey were analyzed ( = 4448). The participants were stratified into four groups according to age (<65 vs. ≥65 years) and sex. Each group was divided into tertiles of vitamin E/total lipid ratio, and Patient Health Questionnaire-9 (PHQ-9) scores were compared among the tertiles via multivariable linear regression analyses. The relationship between dietary supplement use and the proportions of tertiles was assessed in each group. With the middle tertile as the reference group, the low tertile of vitamin E/total lipid ratio was associated with increased PHQ-9 scores in younger females and older males after adjusting for all covariates, while the high tertile showed no significant associations with PHQ-9 scores in any group. The low tertile was associated with increased adjusted mean PHQ-9 scores by 0.53 and 1.02 compared to the middle tertile in younger females and older males, respectively. Dietary supplement use was related to higher vitamin E/total lipid ratio in all four groups. In conclusion, younger females and older males with a low vitamin E status showed worse depressive symptoms. These individuals may benefit from dietary interventions to prevent depressive symptoms.
研究报告显示，血清维生素 E 水平与抑郁症状之间的关系结果不一致。此外，年龄和性别潜在的调节作用尚未得到充分探索。我们在一个大型全国性样本中进行了年龄和性别分层调查，研究血清维生素 E 状况与抑郁症状之间的关系。分析了韩国国家健康和营养检查调查的数据（n=4448）。根据年龄（<65 岁与≥65 岁）和性别将参与者分为四组。根据维生素 E/总脂质比值将每组分为三分位，并通过多变量线性回归分析比较三分位之间的 PHQ-9 评分。在每组中评估了膳食补充剂使用与三分位比例的关系。以中间三分位为参考组，在校正所有协变量后，低维生素 E/总脂质比值三分位与年轻女性和老年男性的 PHQ-9 评分升高相关，而高三分位与任何组的 PHQ-9 评分均无显著相关性。与中间三分位相比，年轻女性和老年男性的低三分位分别与调整后的平均 PHQ-9 评分增加了 0.53 和 1.02。在所有四组中，膳食补充剂的使用与较高的维生素 E/总脂质比值相关。总之，维生素 E 水平较低的年轻女性和老年男性抑郁症状更严重。这些个体可能受益于饮食干预以预防抑郁症状。
