Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Nutrients. 2022 Feb 3;14(3):656. doi: 10.3390/nu14030656.
Recently, it has been discovered that anti-inflammatory and anti-oxidative pathways play a role in depression and anxiety. Lower serum levels of antioxidants, such as vitamin E, have been implicated in both depression and anxiety.
This PROSPERO-registered systematic review (Reference: CRD42021260058) is reported according to PRISMA guidelines. PubMed, EMBASE, CENTRAL, PsycINFO, and CINAHL were searched from inception to June 2021.
Twelve studies were included in this systematic review, and nine in meta-analysis of vitamin E versus placebo. For depression, meta-analysis of 354 participants showed a standardised mean difference of -0.88 (95% CI: -1.54, -0.21; I2 = 87%) favouring vitamin E. For anxiety, meta-analysis of 306 participants showed a standardised mean difference of -0.86 (95% CI: -2.11, 0.40; I2 = 95%) favouring vitamin E. Three of the studies involved a pure comparison of vitamin E against placebo, while others included constituents such as omega-3 fatty acids. Nine of the studies were at low risk of bias, two had some concerns, and one was at high risk of bias.
Vitamin E supplementation has shown inconclusive results in ameliorating both depression and anxiety. Containing a reassuring safety profile and low cost, future studies would be of promise, and they would benefit from both larger sample sizes and from excluding other constituents, such as omega-3 fatty acids, from experimental and comparator arms.
最近发现，抗炎和抗氧化途径在抑郁和焦虑中起作用。抗氧化剂（如维生素 E）的血清水平较低与抑郁和焦虑都有关。
本 PROSPERO 注册的系统评价（参考文献：CRD42021260058）按照 PRISMA 指南进行报告。从成立到 2021 年 6 月，在 PubMed、EMBASE、CENTRAL、PsycINFO 和 CINAHL 上进行了搜索。
本系统评价纳入了 12 项研究，其中 9 项进行了维生素 E 与安慰剂的 meta 分析。对于抑郁，354 名参与者的 meta 分析显示，维生素 E 更优的标准化均数差为-0.88（95%CI：-1.54，-0.21；I2=87%）。对于焦虑，306 名参与者的 meta 分析显示，维生素 E 更优的标准化均数差为-0.86（95%CI：-2.11，0.40；I2=95%）。其中 3 项研究是维生素 E 与安慰剂的纯比较，而其他研究则包含了欧米伽-3 脂肪酸等成分。9 项研究的偏倚风险较低，2 项研究存在一些关注，1 项研究偏倚风险较高。
维生素 E 补充剂在改善抑郁和焦虑方面的效果尚无定论。由于具有令人放心的安全性和低成本，未来的研究可能会有前景，它们将受益于更大的样本量，并从实验和对照组中排除其他成分，如欧米伽-3 脂肪酸。
