Köck Robin, Denkel Luisa, Feßler Andrea T, Eicker Rudolf, Mellmann Alexander, Schwarz Stefan, Geffers Christine, Hübner Nils-Olaf, Leistner Rasmus
Institute of Hygiene, University Hospital Münster, 48149 Münster, Germany.
Hygiene and Environmental Medicine, University Hospital Essen, 45147 Essen, Germany.
Pathogens. 2023 Apr 18;12(4):612. doi: 10.3390/pathogens12040612.
The antiseptic agent octenidine dihydrochloride (OCT) is used for skin preparation, for decolonization, and within bundles for the prevention of catheter-related or surgical site infections (SSIs). Here, we review the evidence for the effects of OCT from clinical studies.
Review of studies published in the Medline, Scopus, and Cochrane databases until August 2022, performed in clinical settings and reporting on effects of OCT on carriage/transmission, SSI prevention, and prevention of intensive care unit (ICU)-related or catheter-related bloodstream and insertion site infections.
We included 31 articles. The success of decolonization with OCT-containing therapies ranged between 6 and 87%. Single studies demonstrated that OCT application led to a reduction in infections, acquisition, and carriage. No study compared OCT for skin preparation before surgical interventions to other antiseptics. Weak evidence for the use of OCT for pre-operative washing was found in orthopedic and cardiac surgery, if combined with other topical measures. Mostly, studies did not demonstrate that daily OCT bathing reduced ICU-/catheter-related bloodstream infections with one exception.
There is a need to perform studies assessing the clinical use of OCT compared with other antiseptics with respect to its effectiveness to prevent nosocomial infections.
抗菌剂二盐酸奥替尼啶（OCT）用于皮肤准备、去定植以及作为预防导管相关感染或手术部位感染（SSI）的集束化护理措施的一部分。在此，我们回顾临床研究中关于OCT效果的证据。
检索Medline、Scopus和Cochrane数据库中截至2022年8月发表的研究，这些研究在临床环境中进行，并报告了OCT对定植/传播、预防SSI以及预防重症监护病房（ICU）相关或导管相关血流感染和插入部位感染的影响。
我们纳入了31篇文章。含OCT疗法去定植的成功率在6%至87%之间。单项研究表明，应用OCT可减少感染、获得和定植。没有研究将手术干预前使用OCT进行皮肤准备与其他抗菌剂进行比较。在骨科和心脏手术中，如果与其他局部措施联合使用，有微弱证据支持术前使用OCT冲洗。大多数研究未表明每日使用OCT沐浴可减少ICU/导管相关血流感染，仅有一项研究例外。
有必要开展研究，评估与其他抗菌剂相比，OCT预防医院感染有效性的临床应用情况。
