流体动力学递送：特性、应用及技术进展
Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances.
作者信息
Suda Takeshi, Yokoo Takeshi, Kanefuji Tsutomu, Kamimura Kenya, Zhang Guisheng, Liu Dexi
机构信息
Department of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma 949-7302, Niigata, Japan.
Department of Preemptive Medicine for Digestive Diseases and Healthy Active Life, School of Medicine, Niigata University, Niigata 951-8510, Niigata, Japan.
出版信息
Pharmaceutics. 2023 Mar 31;15(4):1111. doi: 10.3390/pharmaceutics15041111.
The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal species through systemic or local injection, resulting in significant advances in new applications and technological development. The development of regional hydrodynamic delivery directly supports successful gene delivery in large animals, including humans. This review summarizes the fundamentals of hydrodynamic delivery and the progress that has been made in its application. Recent progress in this field offers tantalizing prospects for the development of a new generation of technologies for broader application of hydrodynamic delivery.
流体动力学递送原理最初被用于开发一种通过尾静脉注射将质粒递送至小鼠肝细胞的方法，并且已扩展到通过全身或局部注射将各种生物活性物质递送至多种动物物种的各种器官中的细胞，从而在新应用和技术发展方面取得了重大进展。区域流体动力学递送的发展直接支持了包括人类在内的大型动物的成功基因递送。本综述总结了流体动力学递送的基本原理及其应用中所取得的进展。该领域的最新进展为流体动力学递送更广泛应用的新一代技术开发提供了诱人的前景。
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