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利用稳健设计优化复合生物黏附剂以促进皮肤伤口修复。

Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair.

作者信息

Pinnaratip Rattapol, Zhang Zhongtian, Smies Ariana, Forooshani Pegah Kord, Tang Xiaoqing, Rajachar Rupak M, Lee Bruce P

机构信息

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.

Department of Biological Sciences, Life Science and Technology Institute, Michigan Technological University, Houghton, MI 49931, USA.

出版信息

Polymers (Basel). 2023 Apr 15;15(8):1905. doi: 10.3390/polym15081905.

DOI:10.3390/polym15081905
PMID:37112052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10144490/
Abstract

Catechol-modified bioadhesives generate hydrogen peroxide (HO) during the process of curing. A robust design experiment was utilized to tune the HO release profile and adhesive performance of a catechol-modified polyethylene glycol (PEG) containing silica particles (SiP). An L orthogonal array was used to determine the relative contributions of four factors (the PEG architecture, PEG concentration, phosphate-buffered saline (PBS) concentration, and SiP concentration) at three factor levels to the performance of the composite adhesive. The PEG architecture and SiP wt% contributed the most to the variation in the results associated with the HO release profile, as both factors affected the crosslinking of the adhesive matrix and SiP actively degraded the HO. The predicted values from this robust design experiment were used to select the adhesive formulations that released 40-80 µM of HO and evaluate their ability to promote wound healing in a full-thickness murine dermal wound model. The treatment with the composite adhesive drastically increased the rate of the wound healing when compared to the untreated controls, while minimizing the epidermal hyperplasia. The release of HO from the catechol and soluble silica from the SiP contributed to the recruitment of keratinocytes to the wound site and effectively promoted the wound healing.

摘要

儿茶酚改性生物粘合剂在固化过程中会产生过氧化氢（HO）。采用稳健设计实验来调节含二氧化硅颗粒（SiP）的儿茶酚改性聚乙二醇（PEG）的HO释放曲线和粘合性能。使用L正交阵列来确定四个因素（PEG结构、PEG浓度、磷酸盐缓冲盐水（PBS）浓度和SiP浓度）在三个因素水平下对复合粘合剂性能的相对贡献。PEG结构和SiP重量百分比对与HO释放曲线相关的结果变化贡献最大，因为这两个因素都影响粘合剂基质的交联，并且SiP会积极降解HO。该稳健设计实验的预测值用于选择释放40 - 80 μM HO的粘合剂配方，并评估它们在全层小鼠皮肤伤口模型中促进伤口愈合的能力。与未处理的对照相比，复合粘合剂处理显著提高了伤口愈合速度，同时将表皮增生降至最低。儿茶酚释放的HO和SiP释放的可溶性二氧化硅有助于角质形成细胞向伤口部位募集，并有效促进伤口愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/9f9715637870/polymers-15-01905-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/75ce048f9d8b/polymers-15-01905-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/c1da8d9a863f/polymers-15-01905-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/9921b500c856/polymers-15-01905-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/a5bf0abfcb21/polymers-15-01905-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/ab01349fa1b3/polymers-15-01905-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/e0d39a121224/polymers-15-01905-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/9f9715637870/polymers-15-01905-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/157d4e631147/polymers-15-01905-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/d9928786cec8/polymers-15-01905-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/9e439adc0180/polymers-15-01905-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/62f5141ace3e/polymers-15-01905-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/178ddfce94ab/polymers-15-01905-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/aef095bfd4f0/polymers-15-01905-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/6821bf86d657/polymers-15-01905-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/5de4042a487c/polymers-15-01905-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/75ce048f9d8b/polymers-15-01905-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/c1da8d9a863f/polymers-15-01905-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/9921b500c856/polymers-15-01905-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/a5bf0abfcb21/polymers-15-01905-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/ab01349fa1b3/polymers-15-01905-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/e0d39a121224/polymers-15-01905-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a38/10144490/9f9715637870/polymers-15-01905-g014.jpg

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ACS Biomater Sci Eng. 2020 Aug 10;6(8):4502-4511. doi: 10.1021/acsbiomaterials.0c00572. Epub 2020 Jun 28.
3
Mussel-inspired hydrogels: from design principles to promising applications.
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J Mater Chem B. 2025 Mar 20;13(12):3967-3979. doi: 10.1039/d4tb01722f.
4
In Vitro Biological Evaluation of an Alginate-Based Hydrogel Loaded with Rifampicin for Wound Care.负载利福平的海藻酸盐基水凝胶用于伤口护理的体外生物学评价
Pharmaceuticals (Basel). 2024 Jul 14;17(7):943. doi: 10.3390/ph17070943.
贻贝启发的水凝胶：从设计原理到有前途的应用。
Chem Soc Rev. 2020 Jun 7;49(11):3605-3637. doi: 10.1039/c9cs00849g. Epub 2020 May 12.
4
Cutaneous wound healing in aged, high fat diet-induced obese female or male C57BL/6 mice.老龄、高脂肪饮食诱导肥胖雌性或雄性 C57BL/6 小鼠的皮肤伤口愈合。
Aging (Albany NY). 2020 Apr 15;12(8):7066-7111. doi: 10.18632/aging.103064.
5
Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications.儿茶酚功能化水凝胶：仿生设计、粘附机制和生物医学应用。
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6
Dermal fibroblasts-A heterogeneous population with regulatory function in wound healing.皮肤成纤维细胞——一种具有调节功能的异质性细胞群体，参与伤口愈合。
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