Department of Biomedical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI, 49931, USA.
Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4224-4228. doi: 10.1002/anie.201700628. Epub 2017 Mar 15.
The engineering of bioadhesives to bind and conform to the complex contour of tissue surfaces remains a challenge. We have developed a novel moldable nanocomposite hydrogel by combining dopamine-modified poly(ethylene glycol) and the nanosilicate Laponite, without the use of cytotoxic oxidants. The hydrogel transitioned from a reversibly cross-linked network formed by dopamine-Laponite interfacial interactions to a covalently cross-linked network through the slow autoxidation and cross-linking of catechol moieties. Initially, the hydrogel could be remolded to different shapes, could recover from large strain deformation, and could be injected through a syringe to adhere to the convex contour of a tissue surface. With time, the hydrogel solidified to adopt the new shape and sealed defects on the tissue. This fit-to-shape sealant has potential in sealing tissues with non-flat geometries, such as a sutured anastomosis.
将生物黏合剂设计成能够黏附并顺应组织表面复杂轮廓仍然是一项挑战。我们通过将多巴胺修饰的聚乙二醇与纳米硅酸盐 Laponite 结合，开发了一种新型可模塑纳米复合水凝胶，而无需使用细胞毒性氧化剂。水凝胶由多巴胺- Laponite 界面相互作用形成的可还原交联网络转变为通过儿茶酚部分的缓慢自氧化和交联形成的共价交联网络。最初，水凝胶可以被重塑成不同的形状，可以从大应变变形中恢复，并且可以通过注射器注射以黏附在组织表面的凸轮廓上。随着时间的推移，水凝胶凝固以采用新的形状并密封组织上的缺陷。这种贴合形状的密封剂在密封非平面几何形状的组织方面具有潜力，例如缝合吻合口。
