Department of Mechanical Engineering, City University of Hong Kong, Hong Kong 999077, China.
Chem Soc Rev. 2020 Jun 7;49(11):3605-3637. doi: 10.1039/c9cs00849g. Epub 2020 May 12.
Mussel-inspired chemistry, owing to its unique and versatile functions to manipulate dynamic molecular-scale interactions, has emerged as a powerful tool for the rational design and synthesis of new hydrogels. In particular, possessing a myriad of unique advantages that are otherwise impossible by conventional counterparts, mussel-inspired hydrogels have been widely explored in numerous fields such as biomedical engineering, soft electronics and actuators, and wearable sensors. Despite great excitement and vigor, a comprehensive and timely review on this emerging topic is missing. In this review, we discuss (1) the fundamental interaction mechanisms underpinning the spectacular wet adhesion in natural mussels and mussel-inspired materials; (2) the key routes to engineering hydrogels by leveraging on the interactions of mussel-inspired building blocks; (3) the emerging applications of mussel-inspired hydrogels, especially in the areas of flexible electronics and biomedical engineering; (4) the future perspectives and unsolved challenges of this multidisciplinary field. We envision that this review will provide an insightful perspective to stimulate new thinking and innovation in the development of next-generation hydrogels and beyond.
受贻贝启发的化学，由于其独特而多样的功能来操控动态分子尺度相互作用，已成为合理设计和合成新型水凝胶的有力工具。特别是，具有许多独特的优势，这是传统对应物不可能具有的，贻贝启发的水凝胶已广泛应用于生物医学工程、软电子和执行器以及可穿戴传感器等众多领域。尽管令人兴奋和充满活力，但这个新兴主题仍然缺乏全面和及时的综述。在这篇综述中，我们讨论了（1）在天然贻贝和贻贝启发材料中产生惊人湿粘附的基本相互作用机制；（2）通过利用贻贝启发的构建块的相互作用来工程化水凝胶的关键途径；（3）贻贝启发水凝胶的新兴应用，特别是在柔性电子和生物医学工程领域；（4）这个多学科领域的未来展望和未解决的挑战。我们设想，这篇综述将提供一个有见地的视角，激发下一代水凝胶及其它相关领域的新思维和创新。
