Université de Haute-Alsace, CNRS, IS2M UMR 7361, F-68100 Mulhouse, France.
Université de Strasbourg, F-67081 Strasbourg, France.
Sensors (Basel). 2023 Apr 14;23(8):3995. doi: 10.3390/s23083995.
Interfacing recognition materials with transducers has consistently presented a challenge in the development of sensitive and specific chemical sensors. In this context, a method based on near-field photopolymerization is proposed to functionalize gold nanoparticles, which are prepared by a very simple process. This method allows in situ preparation of a molecularly imprinted polymer for sensing by surface-enhanced Raman scattering (SERS). In a few seconds, a functional nanoscale layer is deposited by photopolymerization on the nanoparticles. In this study, the dye Rhodamine 6G was chosen as a model target molecule to demonstrate the principle of the method. The detection limit is 500 pM. Due to the nanometric thickness, the response is fast, and the substrates are robust, allowing regeneration and reuse with the same performance level. Finally, this method of manufacturing has been shown to be compatible with integration processes, allowing the future development of sensors integrated in microfluidic circuits and on optical fibers.
在敏感和特异性化学传感器的开发中，识别材料与换能器的接口一直是一个挑战。在这种情况下，提出了一种基于近场光聚合的方法来功能化金纳米粒子，该方法通过非常简单的过程制备。该方法允许通过表面增强拉曼散射（SERS）原位制备用于传感的分子印迹聚合物。在几秒钟内，通过光聚合在纳米颗粒上沉积功能纳米级层。在这项研究中，选择染料 Rhodamine 6G 作为模型靶分子来证明该方法的原理。检测限为 500 pM。由于纳米级厚度，响应速度快，且基底坚固，可进行再生和重复使用，性能水平相同。最后，已经表明这种制造方法与集成工艺兼容，允许在微流控电路和光纤上集成传感器的未来发展。
