The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
The Institute of Translational Medicine, Zhejiang University, Hangzhou, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Mar;13(2):e1672. doi: 10.1002/wnan.1672. Epub 2020 Oct 18.
Surface-enhanced Raman scattering (SERS) technique has been regarded as one of the most important research methods in the field of single-molecule science. Since the previous decade, the application of nanoparticles for in vivo SERS imaging becomes the focus of research. To enhance the performance of SERS imaging, researchers have developed several SERS nanotags such as gold nanostars, copper-based nanomaterials, semiconducting quantum dots, and so on. The development of Raman equipment is also necessary owing to the current limitations. This review describes the recent advances of SERS nanoparticles and their applications for in vivo imaging in detail. Specific examples highlighting the in vivo cancer imaging and treatment application of SERS nanoparticles. A perspective on the challenges and opportunities of nanoparticles in SERS in vivo imaging is also provided. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
表面增强拉曼散射（SERS）技术已被视为单分子科学领域最重要的研究方法之一。在过去十年中，用于体内 SERS 成像的纳米颗粒的应用成为研究的焦点。为了增强 SERS 成像的性能，研究人员开发了几种 SERS 纳米标签，如金纳米星、基于铜的纳米材料、半导体量子点等。由于目前的限制，还需要开发拉曼设备。本文详细描述了 SERS 纳米颗粒的最新进展及其在体内成像中的应用。特别强调了 SERS 纳米颗粒在体内癌症成像和治疗应用方面的实例。还提供了对纳米颗粒在体内 SERS 成像中面临的挑战和机遇的看法。本文属于以下分类：诊断工具 > 体内纳米诊断和成像 治疗方法和药物发现 > 用于肿瘤疾病的纳米医学。
