Jeyarajah R, Samarawickrama P, Jameel M M
J Chronic Dis. 1986;39(6):479-84. doi: 10.1016/0021-9681(86)90115-3.
Traditionally accepted symptoms suggestive of autonomic neuropathy (ANP) were elicited in 65 non-insulin dependent diabetic patients attending a diabetic clinic and four autonomic function tests (AFTs) were performed in these diabetics and 60 non-diabetic healthy volunteers. Though 18 (27.6%) diabetics had symptoms of ANP, none of these symptoms were severe. AFTs were abnormal in 30 (46.2%) diabetics and 9 (15%) healthy volunteers. AFT abnormalities in diabetics were found more frequently than symptoms would suggest (21, i.e. 70% of the 30 diabetics did not have symptoms of ANP). There was poor correlation between symptoms of ANP and AFT abnormalities (only 9 of the 18 diabetics with symptoms of ANP had abnormal AFTs). Of the four AFTs performed, R-R variation was the commonest abnormality occurring in 17 of the 30 diabetics with abnormal AFTs. The prevalence of AFT abnormalities did not increase significantly with the duration of diabetes (chi 2 = 0.42; p = 0.8392), but increased significantly with the advancing age of the diabetics (chi 2 = 11.14; p less than 0.005). In healthy volunteers, the test values for standard deviation for R-R variation in deep breathing decreased significantly (p less than 0.05) with the advancing age of the subjects.
在一家糖尿病诊所就诊的65名非胰岛素依赖型糖尿病患者中，引发了传统上公认的提示自主神经病变（ANP）的症状，并对这些糖尿病患者和60名非糖尿病健康志愿者进行了四项自主神经功能测试（AFT）。虽然18名（27.6%）糖尿病患者有ANP症状，但这些症状均不严重。30名（46.2%）糖尿病患者和9名（15%）健康志愿者的AFT异常。糖尿病患者中AFT异常的发现频率高于症状所提示的频率（21例，即30名糖尿病患者中有70%没有ANP症状）。ANP症状与AFT异常之间的相关性较差（18名有ANP症状的糖尿病患者中只有9名AFT异常）。在进行的四项AFT中，R-R变异是最常见的异常，在30名AFT异常的糖尿病患者中有17名出现。AFT异常的患病率并未随糖尿病病程显著增加（χ2 = 0.42；p = 0.8392），但随糖尿病患者年龄增长显著增加（χ2 = 11.14；p < 0.005）。在健康志愿者中，随着受试者年龄增长，深呼吸时R-R变异的标准差测试值显著降低（p < 0.05）。
