Jermendy G, Koltai M Z, Pogátsa G
Merényi Kóráz Belgyóhyászti Osztály, Budapest.
Acta Diabetol Lat. 1990 Oct-Dec;27(4):295-301. doi: 10.1007/BF02580933.
QT interval alterations were measured in 41 non-insulin-dependent (type 2) diabetic patients and 14 age- and sex-matched control subjects. Cardiac autonomic neuropathy (CAN) was assessed by noninvasive tests (deep breathing, Valsalva maneuver and lying-to-standing) and diabetics were divided into three groups according to the results of these tests: diabetics with definitive (n = 14), early (n = 13) and without (n = 14) CAN. The corrected values of QT intervals (QTc) at rest were significantly longer in diabetics with definitive (447 +/- 5 ms; p less than 0.001), early (426 +/- 5 ms; p less than 0.05) and without (424 +/- 5 ms; p less than 0.05) CAN than in controls (407 +/- 5 ms). Moreover, QTc intervals at rest were significantly (p less than 0.01) longer in diabetics with definitive CAN than in diabetics with early and without CAN. QTc intervals at maximum tachycardia, induced by Valsalva maneuver, were considerably longer in diabetics with definitive CAN (451 +/- 6 ms) than in controls (407 +/- 6 ms; p less than 0.001) and in diabetics with early (434 +/- 6 ms; p less than 0.05) or without (422 +/- 6 ms; p less than 0.01) CAN. Furthermore, QTc intervals at maximum tachycardia were significantly (p less than 0.01) longer in diabetics with early CAN than in controls.(ABSTRACT TRUNCATED AT 250 WORDS)
对41例非胰岛素依赖型（2型）糖尿病患者和14例年龄及性别匹配的对照者进行了QT间期改变的测量。通过非侵入性试验（深呼吸、瓦尔萨尔瓦动作和卧立位试验）评估心脏自主神经病变（CAN），并根据这些试验结果将糖尿病患者分为三组：确诊CAN的糖尿病患者（n = 14）、早期CAN的糖尿病患者（n = 13）和无CAN的糖尿病患者（n = 14）。确诊CAN的糖尿病患者（447±5毫秒；p<0.001）、早期CAN的糖尿病患者（426±5毫秒；p<0.05）和无CAN的糖尿病患者（424±5毫秒；p<0.05）静息时的校正QT间期（QTc）显著长于对照组（407±5毫秒）。此外，确诊CAN的糖尿病患者静息时的QTc间期显著（p<0.01）长于早期和无CAN的糖尿病患者。瓦尔萨尔瓦动作诱发的最大心动过速时的QTc间期，确诊CAN的糖尿病患者（451±6毫秒）显著长于对照组（407±6毫秒；p<0.001）以及早期（434±6毫秒；p<0.05）或无CAN（422±6毫秒；p<0.01）的糖尿病患者。此外，早期CAN的糖尿病患者最大心动过速时的QTc间期显著（p<0.01）长于对照组。（摘要截选至250词）
