Prueksaanantakal Naphatthorn, Manomaipiboon Anan, Phankavong Patchara, Jirawathin Warissara, Benjakul Nontawat, Maneerit Jakravoot, Phumisantiphong Uraporn, Trakarnvanich Thananda
Kuakarun Faculty of Nursing, Navamindradhiraj University, Bangkok 10300, Thailand.
Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand.
Vaccines (Basel). 2023 Mar 27;11(4):741. doi: 10.3390/vaccines11040741.
In the current study, we calculated the vaccine volume and amount of dead space in a syringe and needle during ChAdox1-n CoV vaccine administration using the air-filled technique. The aim is to reduce the dead space in syringes and needles in order to administer up to 12 doses per vial. The hypothetical situation uses a vial with a similar size as the ChAdox1-n CoV vial. We used distilled water (6.5 mL) to fill the same volume as five vials of ChAdox1-n CoV. When 0.48 mL of distilled water is drawn according to the number on the side of the barrel, an additional 0.10 mL of air can be used in the dead space of the distilled water in the syringe and needle for 60 doses, which can be divided into an average of 0.5 mL per dose. ChAdox1-n CoV was administered using a 1-mL syringe and 25G needle into 12 doses using this air-filled technique. The volume of the recipient vaccine will increase by 20% and save on the budget for low dead space syringes (LDS).
在本研究中，我们使用空气填充技术计算了在接种ChAdox1-n CoV疫苗期间注射器和针头中的疫苗体积和死腔量。目的是减少注射器和针头中的死腔，以便每瓶最多接种12剂。假设情况使用的小瓶尺寸与ChAdox1-n CoV小瓶相似。我们用蒸馏水（6.5 mL）填充与五瓶ChAdox1-n CoV相同的体积。当根据针筒侧面的数字抽取0.48 mL蒸馏水时，在注射器和针头中蒸馏水的死腔中可额外使用0.10 mL空气用于60剂接种，平均每剂可分为0.5 mL。使用1 mL注射器和25G针头，采用这种空气填充技术将ChAdox1-n CoV接种为12剂。接受者疫苗的体积将增加20%，并节省低死腔注射器（LDS）的预算。
