免疫印记及其对新冠病毒病的影响
Immune Imprinting and Implications for COVID-19.
作者信息
Zhou Zhiqian, Barrett Julia, He Xuan
机构信息
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Department of Respiratory and Critical Care Medicine, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610213, China.
出版信息
Vaccines (Basel). 2023 Apr 20;11(4):875. doi: 10.3390/vaccines11040875.
Immunological memory is the key source of protective immunity against pathogens. At the current stage of the COVID-19 pandemic, heterologous combinations of exposure to viral antigens during infection and/or vaccination shape a distinctive immunological memory. Immune imprinting, the downside of memory, might limit the generation of immune response against variant infection or the response to the next-generation vaccines. Here, we review mechanistic basis of immune imprinting by focusing on B cell immunobiology and discuss the extent to which immune imprinting is harmful, as well as its effect on SARS-CoV-2 infection and vaccination.
免疫记忆是针对病原体的保护性免疫的关键来源。在新冠疫情的当前阶段，感染期间和/或接种疫苗时接触病毒抗原的异源组合塑造了独特的免疫记忆。免疫印记作为记忆的负面影响，可能会限制针对变异株感染的免疫反应的产生或对下一代疫苗的反应。在这里，我们通过关注B细胞免疫生物学来综述免疫印记的机制基础，并讨论免疫印记的有害程度及其对新冠病毒感染和疫苗接种的影响。
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