抗炎活性： 及 亚种（特雷尔）中存在的皂苷元的抗炎活性。 （你提供的原文似乎不完整，部分内容表述不太清晰准确，可能影响翻译的精准度）
Anti-inflammatory Activity: and of Sapogenins Present in subsp. (Trel.).
作者信息
Resino-Ruiz Dayana, Gonzalez-Madariaga Yisel, Nieto Leisy, Linares Yilka Mena, León Jose Orestes Guerra, Martín Arlena Vázquez, Díaz Arianna Valido, Torrens Francisco, Castillo-Garit Juan A
机构信息
Unidad de Toxicología Experimental, Universidad de Ciencias Médicas de Villa Clara, Santa Clara, 50200, Villa Clara, Cuba.
Departamento de Farmacia, Facultad de Química-Farmacia, Universidad Central "Marta Abreu" de Las Villas, Santa Clara, 54830, Villa Clara, Cuba.
出版信息
Antiinflamm Antiallergy Agents Med Chem. 2023;22(1):42-48. doi: 10.2174/1871523022666230419103027.
BACKGROUND
Agave brittoniana subsp. brachypus is an endemic plant of Cuba, which contains different steroidal sapogenins with anti-inflammatory effects. This work aims to develop computational models which allow the identification of new chemical compounds with potential anti-inflammatory activity.
METHODS
The in vivo anti-inflammatory activity was evaluated in two rat models: carrageenaninduced paw edema and cotton pellet-induced granuloma. In each study, we used 30 Sprague Dawley male rats divided into five groups containing six animals. The products isolated and administrated were fraction rich in yuccagenin and sapogenins crude.
RESULTS
The obtained model, based on a classification tree, showed an accuracy value of 86.97% for the training set. Seven compounds (saponins and sapogenins) were identified as potential antiinflammatory agents in the virtual screening. According to in vivo studies, the yuccagenin-rich fraction was the greater inhibitor of the evaluated product from Agave.
CONCLUSION
The evaluated metabolites of the Agave brittoniana subsp. Brachypus showed an interesting anti-inflammatory effect.
背景
短叶龙舌兰（Agave brittoniana subsp. brachypus）是古巴的一种特有植物，含有具有抗炎作用的不同甾体皂苷元。这项工作旨在开发计算模型，以识别具有潜在抗炎活性的新化合物。
方法
在两种大鼠模型中评估体内抗炎活性：角叉菜胶诱导的爪肿胀和棉球诱导的肉芽肿。在每项研究中，我们使用30只雄性Sprague Dawley大鼠，分为五组，每组六只动物。分离并给予的产物是富含丝兰皂苷元和皂苷元粗品的馏分。
结果
基于分类树得到的模型在训练集上的准确率为86.97%。在虚拟筛选中，七种化合物（皂苷和皂苷元）被鉴定为潜在的抗炎剂。根据体内研究，富含丝兰皂苷元的馏分是龙舌兰评估产物中更强的抑制剂。
结论
短叶龙舌兰（Agave brittoniana subsp. Brachypus）评估的代谢产物显示出有趣的抗炎作用。
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