Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430015, PR China.
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430015, PR China.
Int Immunopharmacol. 2023 Jun;119:110221. doi: 10.1016/j.intimp.2023.110221. Epub 2023 Apr 28.
Psoriasis is a common chronic inflammatory skin disease that is easy to relapse and difficult to cure. Piperine is the main alkaloid extracted from black pepper, and its role in psoriasis has not been previously reported. We identified that piperine ameliorated M5-induced psoriatic skin lesions. Furthermore, piperine alleviated psoriasis pathological features including epidermal hyperplasia and inflammatory cell infiltration, decreased the expression of psoriasis-characteristic cytokines, chemokines and proteins in IMQ-induced psoriasiform dermatitis. Moreover, we determined that piperine inhibited the phosphorylation of STAT3 in M5- and IMQ-induced psoriasis-like skin lesions. Our data demonstrated that piperine ameliorated psoriatic skin inflammation by inhibiting the phosphorylation of STAT3. Therefore, piperine may be one potential compound candidate for psoriasis therapy, providing new strategies for clinical intervention.
银屑病是一种常见的慢性炎症性皮肤病，容易复发，难以治愈。胡椒碱是从黑胡椒中提取的主要生物碱，其在银屑病中的作用尚未见报道。我们发现胡椒碱可改善 M5 诱导的银屑病皮肤损伤。此外，胡椒碱减轻了银屑病的病理特征，包括表皮增生和炎症细胞浸润，降低了 IMQ 诱导的银屑病样皮炎中银屑病特征性细胞因子、趋化因子和蛋白的表达。此外，我们确定胡椒碱抑制了 M5 和 IMQ 诱导的银屑病样皮肤损伤中 STAT3 的磷酸化。我们的数据表明，胡椒碱通过抑制 STAT3 的磷酸化改善了银屑病皮肤炎症。因此，胡椒碱可能是治疗银屑病的一种有潜力的化合物候选物，为临床干预提供了新的策略。
