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抗衰老领域的最新进展:用于皮肤护理的植物源植物化学物质。

The state of the art in anti-aging: plant-based phytochemicals for skin care.

作者信息

Tomas Merve, Günal-Köroğlu Deniz, Kamiloglu Senem, Ozdal Tugba, Capanoglu Esra

机构信息

Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469, Maslak, Istanbul, Türkiye.

Department of Food Engineering, Faculty of Agriculture, Bursa Uludag University, 16059, Gorukle, Bursa, Türkiye.

出版信息

Immun Ageing. 2025 Jan 31;22(1):5. doi: 10.1186/s12979-025-00498-9.

Abstract

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, and reducing levels of inflammatory markers (IL-6, IL-8, etc.) and matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. This review explores the multifaceted roles of phytochemicals in maintaining and improving skin health, highlighting their mechanisms of action and potential in skin anti-aging innovations.

摘要

植物化学物质通过清除自由基、调节关键酶促途径和促进皮肤结构完整性来帮助减轻皮肤衰老。类胡萝卜素、维生素、必需脂肪酸和酚类化合物通过充当抗氧化剂、抑制透明质酸酶、胶原酶和弹性蛋白酶等降解皮肤结构的酶以及降低与衰老相关的炎症标志物(白细胞介素-6、白细胞介素-8等)和基质金属蛋白酶(基质金属蛋白酶-1、基质金属蛋白酶-2)的水平来发挥作用。最近的研究强调,基于植物的植物化学物质可以改善皮肤弹性、减少色素沉着、防止重要皮肤蛋白质的分解并支持伤口愈合,使其成为皮肤护理和治疗的有价值成分。本综述探讨了植物化学物质在维持和改善皮肤健康方面的多方面作用,强调了它们的作用机制以及在皮肤抗衰创新中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00d9/11783858/655eb689441b/12979_2025_498_Fig1_HTML.jpg

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