Hamaura T, Nakane S, Hashida M, Sezaki H
J Pharmacobiodyn. 1986 Jan;9(1):12-7. doi: 10.1248/bpb1978.9.12.
The effect of temperature on the transfer and the tissue uptake of sulfanilamide and aminopropyron, an aminopyrine derivative, was investigated using the everted and the non-everted sacs of rat intestine. The M (mucosa) to S (serosa) transfer of sulfanilamide was slightly faster than reverse S-to-M in the ileum at the temperatures studied. Decreased transfer and tissue uptake of sulfanilamide with decreasing temperature were observed using both ileal everted and non-everted sacs. On the contrary, the M-to-S transfer of aminopropyron was slower than the S-to-M transfer in the ileum. The tissue uptake of aminopropyron was almost constant at any temperature in the ileal non-everted sac experiments, while a decreased transfer of aminopropyron was observed with a decrease in temperature. Similar results, like aminopropyron in the ileum, were obtained in the experiments of aminopropyron and sulfanilamide using the colonic sacs. It is concluded that a close relationship may exist between the directional superiority in the transfer and the temperature independency of the tissue uptake.
利用大鼠肠外翻和非外翻肠囊，研究了温度对磺胺和氨基丙基龙（氨基比林衍生物）转运及组织摄取的影响。在所研究的温度下，磺胺在回肠中的黏膜（M）向浆膜（S）的转运略快于反向的S向M转运。使用回肠外翻和非外翻肠囊均观察到，随着温度降低，磺胺的转运和组织摄取减少。相反，氨基丙基龙在回肠中的M向S转运比S向M转运慢。在回肠非外翻肠囊实验中，氨基丙基龙的组织摄取在任何温度下几乎恒定，而随着温度降低，氨基丙基龙的转运减少。在使用结肠囊进行的氨基丙基龙和磺胺实验中，获得了与回肠中氨基丙基龙类似的结果。结论是，转运的方向性优势与组织摄取的温度独立性之间可能存在密切关系。
