[大鼠体重对采用外翻肠囊法进行镍的体外肠吸收的影响]

[The effect of the live weight of rats on the intestinal in vitro absorption of nickel using everted intestinal sacs].

作者信息

Eidelsburger U, Kirchgessner M

机构信息

Institut für Ernährungsphysiologie, Technischen Universität München in Freising-Weihenstephan, Germany.

出版信息

Arch Tierernahr. 1996;49(4):287-91. doi: 10.1080/17450399609381891.

DOI:10.1080/17450399609381891

PMID:9065307

Abstract

The influence of the live weight of the experimental animals on the Ni absorption was investigated in vitro with everted sacs from rats. Totally 75 male rats in the live weight range from 30 to 250 g were used. With increasing live weight the Ni uptake by the intestinal wall and the Ni transfer across the intestinal wall decreased significantly. Ni transfer was already significantly reduced by 45% when body weight increased from 30 to 60 g. For the animals with a live weight above 200 g Ni transfer reached only about 10% of the Ni transfer measured for the animals with 30 g live weight. The decline of the Ni uptake by the intestinal wall was only slightly in the live weight range from 30 to 150 g. Within the live weights higher than 190 g Ni uptake by the intestinal wall decreased significantly to about 25% compared to the animals with 30 g live weight.

摘要

利用大鼠外翻肠囊在体外研究了实验动物体重对镍吸收的影响。总共使用了75只体重在30至250克之间的雄性大鼠。随着体重增加，肠壁对镍的摄取以及镍穿过肠壁的转移显著降低。当体重从30克增加到60克时，镍转移已经显著减少了45%。对于体重超过200克的动物，镍转移仅达到体重30克动物所测镍转移量的约10%。在30至150克的体重范围内，肠壁对镍的摄取下降幅度较小。在体重高于190克时，与体重30克的动物相比，肠壁对镍的摄取显著下降至约25%。