Mengstie Misganaw Asmamaw, Seid Mohammed Abdu, Gebeyehu Natnael Atnafu, Adella Getachew Asmare, Kassie Gizchew Ambaw, Bayih Wubet Alebachew, Gesese Molalegn Mesele, Anley Denekew Tenaw, Feleke Sefineh Fenta, Zemene Melkamu Aderajew, Dessie Anteneh Mengist, Solomon Yenealem, Bantie Berihun, Dejenie Tadesse Asmamaw, Teshome Assefa Agegnehu, Abebe Endeshaw Chekol
Department of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Metabol Open. 2023 Apr 11;18:100243. doi: 10.1016/j.metop.2023.100243. eCollection 2023 Jun.
Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.
糖尿病肾病（DN）是糖尿病最常见的并发症，长期以来一直影响着糖尿病患者的生活。大量研究表明，铁死亡与肾细胞损伤之间存在着紧密的联系。铁死亡是一种铁依赖性、非凋亡性、受调控的细胞死亡，其特征是细胞内脂质过氧化物积累到致死水平。虽然凋亡、自噬和坏死性凋亡等程序性细胞死亡在DN发病机制中的作用已得到证实，但铁死亡在DN中的影响却很少受到关注。因此，本综述的主要目的是讨论目前对铁死亡的认识，重点关注其潜在机制、在DN中的作用以及新出现的治疗机会。
