Micrognathia as a Diagnosis Marker for the Prenatal Identification of Edwards Syndrome.

Edwards syndrome, or trisomy 18, is a severe chromosomal disorder marked by numerous congenital anomalies, including micrognathia. This study evaluated the diagnostic significance of micrognathia as a prenatal indicator for trisomy 18 through a case series involving five confirmed instances. Ultrasound assessments concentrated on the inferior facial angle (IFA) and the jaw index, supplemented by Non-Invasive Prenatal Testing (NIPT) and karyotyping. Micrognathia was consistently identified alongside other anomalies, reinforcing its reliability as an ultrasound marker for trisomy 18. The findings highlight the critical nature of early detection for informed parental counseling and effective pregnancy management.