Martínez Rafael J García, Gea Clara Sanz, Martin-Riera Víctor, Ruiz Armando Raúl Guerra, Barzanti Rosanna Paciucci, Ferrer-Costa Roser, Ramirez-Serra Clara
Clinical Analysis Department, Marqués de Valdecilla University Hospital, Santander, Spain.
Evidence-Based Laboratory Medicine Commission, Spanish Society of Laboratory Medicine (SEQCML), Barcelona, España.
EJIFCC. 2023 Apr 18;34(1):76-80. eCollection 2023 Apr.
Dasatinib is a tyrosine kinase inhibitor drug used for chronic myeloid leukaemia (CML) treatment. Chylothorax has been rarely reported as a secondary effect of dasatinib occurring especially in long-term treated patients, although its pathophysiology is not yet fully understood. Laboratory analysis of the pleural effusion is crucial for chylothorax diagnosis. We report a case of a 53-year-old male patient presenting a chylothorax after 14 years of dasatinib therapy where the clinical laboratory was key in the diagnosis.
达沙替尼是一种用于治疗慢性髓性白血病（CML）的酪氨酸激酶抑制剂药物。乳糜胸作为达沙替尼的一种罕见的副作用，尤其在长期治疗的患者中出现，尽管其病理生理学尚未完全明确。胸腔积液的实验室分析对于乳糜胸的诊断至关重要。我们报告了一例53岁男性患者，在接受达沙替尼治疗14年后出现乳糜胸，其中临床实验室检查对诊断起到了关键作用。
