Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
ACS Appl Bio Mater. 2023 May 15;6(5):1992-2002. doi: 10.1021/acsabm.3c00205. Epub 2023 May 1.
A traditional injectable photocrosslinked hydrogel had disadvantages of the residual photoinitiator and toxic crosslinker, slow curing, and a complex preparation process. At the same time, hydrogels cannot act as artificial skin to restore skin sensory function during the wound healing cycle. In this work, an injectable photocrosslinked hydrogel was prepared which can be quickly cured without photoinitiator. Oxidized sodium alginate was used as a natural macromolecular crosslinking agent to form an injectable hydrogel framework with the photosensitive polymer polyvinyl alcohol bearing styrylpyridinium group (PVA-SBQ). In addition, the hydrogel was endowed with photothermal therapy property after the introduction of biomass-like polydopamine particles. When used as a wound dressing, the hydrogel exhibited an excellent antibacterial property, with an antibacterial rate of 99.56% and 97.96% . As a result, the hydrogel could significantly accelerate the repair of infected wounds, with a wound healing rate of 96.45% after 14 days. Moreover, the hydrogel exhibited a sensitive and stable sensing property, making it promising to reconstitute the sensory function of damaged skin during treatment. This work provides an idea for the development of injectable photocrosslinked hydrogel dressing.
一种传统的可注射光交联水凝胶存在残留光引发剂和有毒交联剂、固化缓慢以及制备工艺复杂等缺点。同时，水凝胶不能作为人工皮肤在伤口愈合周期中恢复皮肤的感觉功能。在这项工作中，制备了一种无需光引发剂即可快速固化的可注射光交联水凝胶。氧化的海藻酸钠被用作天然的大分子交联剂，与带有苯乙烯吡啶基团的光敏聚合物聚乙烯醇（PVA-SBQ）形成可注射水凝胶骨架。此外，水凝胶在引入类生物质聚多巴胺颗粒后具有光热治疗性能。当用作伤口敷料时，水凝胶表现出优异的抗菌性能，抗菌率达 99.56%和 97.96%。结果，水凝胶能够显著加速感染伤口的修复，在 14 天后的愈合率达到 96.45%。此外，水凝胶表现出敏感且稳定的传感性能，有望在治疗过程中重建受损皮肤的感觉功能。这项工作为开发可注射光交联水凝胶敷料提供了思路。
