Kobayashi H, Hobara T, Sakai T
Sangyo Igaku. 1986 Jan;28(1):28-33. doi: 10.1539/joh1959.28.28.
Effects of 1,1,1-trichloroethane (1,1,1-TCE) inhalation on the afferent impulse of the aortic nerve and aortic blood pressure were investigated in anesthetized dogs. In acute inhalation experiment, the threshold concentration of 1,1,1-TCE required to produce a decrease in the aortic nerve activity was approximately 0.4% in inspired air. Moreover, this threshold level and the threshold concentration required to produce a decrease in aortic blood pressure were identical in value. The aortic nerve activity obviously decreased and at the same time was accompanied by a marked decrease in aortic blood pressure following inhalation of high 1,1,1-TCE concentration. These results suggest that the afferent pathway of aortic baroreflex may be operated at a concentration of more than 0.4% in inspired air. It is further suggested that baroreceptor reflex plays a major role in the control of arterial blood pressure following acute 1,1,1-TCE inhalation in anesthetized dogs.
在麻醉犬中研究了吸入1,1,1-三氯乙烷（1,1,1-TCE）对主动脉神经传入冲动和主动脉血压的影响。在急性吸入实验中，引起主动脉神经活动降低所需的1,1,1-TCE阈浓度在吸入空气中约为0.4%。此外，该阈值水平与引起主动脉血压降低所需的阈浓度在数值上相同。吸入高浓度1,1,1-TCE后，主动脉神经活动明显降低，同时伴有主动脉血压显著下降。这些结果表明，主动脉压力反射的传入途径可能在吸入空气中浓度超过0.4%时起作用。进一步表明，在麻醉犬急性吸入1,1,1-TCE后，压力感受器反射在动脉血压控制中起主要作用。
