Rangwala Umme Salma, Tashrifwala Fatema, Egbert Nikita N, Asif Abuzar A
Internal Medicine, Mahatma Gandhi Memorial Medical College, Indore, IND.
Internal Medicine, University of Mauritius, Belle Rive, MUS.
Cureus. 2023 Mar 29;15(3):e36887. doi: 10.7759/cureus.36887. eCollection 2023 Mar.
The rising prevalence of diabetes mellitus brings with it a rise in the occurrence of several complications of the disease such as chronic non-healing wounds. Diabetics are more prone to developing chronic wounds due to complications like peripheral neuropathy, poor foot care, hyperglycaemia and peripheral vascular diseases. The aim of this review is to discuss the various imbalances in the cytokine environment of diabetic wounds and to explore the developments in their management with an emphasis on agents that may be used topically to aid the healing process of chronic wounds. A systematic search was conducted on Scopus, PubMed and Google Scholar and relevant articles were shortlisted. We conclude that increased blood sugar impairs most phases of wound healing in several ways. Supplementary therapy with either topical or systemic cytokines is shown to promote wound healing in a diabetic wound.
糖尿病患病率的上升伴随着该疾病多种并发症发生率的上升，如慢性不愈合伤口。由于周围神经病变、足部护理不佳、高血糖和周围血管疾病等并发症，糖尿病患者更容易发生慢性伤口。本综述的目的是讨论糖尿病伤口细胞因子环境中的各种失衡，并探讨其治疗进展，重点是可局部使用以辅助慢性伤口愈合过程的药物。在Scopus、PubMed和谷歌学术上进行了系统检索，并筛选出相关文章。我们得出结论，血糖升高会通过多种方式损害伤口愈合的大多数阶段。局部或全身使用细胞因子的补充疗法已被证明可促进糖尿病伤口的愈合。
