Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.
LanZhou University of Technology, 287 Langongping Road, Qilihe District, Lanzhou, Gansu, China.
Adv Ther. 2020 Nov;37(11):4519-4537. doi: 10.1007/s12325-020-01499-4. Epub 2020 Sep 15.
Mast cells (MCs) are granulated, immune cells of the myeloid lineage that are present in connective tissues. Apart from their classical role in allergies, MCs also mediate various inflammatory responses due to the nature of their secretory products. They are involved in important physiological and pathophysiological responses related to inflammation, chronic wounds, and autoimmune diseases. There are also indications that MCs are associated with diabetes and its complications. MCs and MC-derived mediators participate in all wound healing stages and are involved in the pathogenesis of non-healing, chronic diabetic foot ulcers (DFUs). More specifically, recent work has shown increased degranulation of skin MCs in human diabetes and diabetic mice, which is associated with impaired wound healing. Furthermore, MC stabilization, either systemic or local at the skin level, improves wound healing in diabetic mice. Understanding the precise role of MCs in wound progression and healing processes can be of critical importance as it can lead to the development of new targeted therapies for diabetic foot ulceration, one of the most devastating complications of diabetes.
肥大细胞（MCs）是存在于结缔组织中的粒细胞免疫细胞，属于骨髓谱系。除了在过敏中的经典作用外，由于其分泌产物的性质，MCs 还介导各种炎症反应。它们参与与炎症、慢性伤口和自身免疫性疾病相关的重要生理和病理生理反应。也有迹象表明，MCs 与糖尿病及其并发症有关。MCs 和 MC 衍生的介质参与所有伤口愈合阶段，并参与非愈合性慢性糖尿病足溃疡（DFUs）的发病机制。更具体地说，最近的工作表明，人类糖尿病和糖尿病小鼠皮肤 MCs 的脱颗粒增加，这与伤口愈合受损有关。此外，MC 稳定化，无论是全身性的还是皮肤水平的局部性的，都可以改善糖尿病小鼠的伤口愈合。了解 MCs 在伤口进展和愈合过程中的精确作用至关重要，因为它可能导致开发针对糖尿病足溃疡的新靶向治疗方法，糖尿病足溃疡是糖尿病最具破坏性的并发症之一。
