Jeyaraman Madhan, Jeyaraman Naveen, Nallakumarasamy Arulkumar, Iyengar Karthikeyan P, Jain Vijay Kumar, Potty Anish G, Gupta Ashim
Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India.
Department of Orthopaedics, South Texas Orthopaedic Research Institute, Laredo, TX 78045, United States.
World J Orthop. 2023 Sep 18;14(9):662-668. doi: 10.5312/wjo.v14.i9.662.
The irrational and prolonged use of antibiotics in orthopaedic infections poses a major threat to the development of antimicrobial resistance. To combat antimicrobial resistance, researchers have implemented various novel and innovative modalities to curb infections. Nanotechnology involves doping ions/metals onto the scaffolds to reach the target site to eradicate the infective foci. In this connotation, we reviewed silver nanoparticle technology in terms of mechanism of action, clinical applications, toxicity, and regulatory guidelines to treat orthopaedic infections.
骨科感染中抗生素的不合理和长期使用对抗菌药物耐药性的发展构成了重大威胁。为了对抗抗菌药物耐药性，研究人员采用了各种新颖和创新的方法来控制感染。纳米技术包括将离子/金属掺杂到支架上，以到达靶位点根除感染灶。在此背景下，我们从作用机制、临床应用、毒性和治疗骨科感染的监管指南等方面对银纳米颗粒技术进行了综述。
