Nielsen Sebastian Kinnberg, Nouhravesh Nina, Jensen Mads Hashiba, Jensen Rawia Farah Gedde, Klein Mads Falk, Saghir Zaigham, Nielsen Dorte, Schou Morten, Lamberts Morten
Department of Cardiology, Herlev-Gentofte University Hospital, Copenhagen, Denmark.
Department of Surgery, Herlev-Gentofte University Hospital, Copenhagen, Denmark.
Clin Epidemiol. 2023 Apr 25;15:483-491. doi: 10.2147/CLEP.S401554. eCollection 2023.
BACKGROUND/AIM: The Danish National Patient Registry (DNPR) provides unique epidemiological insight, but often lacks granular data. We propose a procedure-based definition of cancer status in patients with breast-, lung- and colorectal cancer, which can be applied to administrative health databases. New definitions of cancer status are needed as mortality and morbidity are closely linked to cancer status, yet most studies only use duration since cancer diagnosis as a severity marker. The aim of the study was to validate a new pragmatic definition.
Medical journals of 600 patients, with breast-, lung- and colorectal cancer from the Department of Oncology at Herlev-Gentofte Hospital were retrospectively reviewed. We defined active cancer as a cancer diagnosis, not followed by a potentially curative procedure within 6 months of the diagnosis. The remaining patients were characterized as having non-active cancer. This dichotomization was then compared to a cancer status assessment based on treatment received and paraclinical test such as their first post-procedural control scan. Based on this comparison, we calculated the positive predictive value (PPV) of our definitions of active and non-active cancer.
The calculated PPVs for active breast-, lung- and colorectal cancer were 87% (CI 95%: 0.74-0.99), 91% (CI 95%: 0.87-0.96) and 82% (CI 95%: 0.73-0.91). The PPVs for non-active breast-, lung- and colorectal cancer were 95% (CI 95%: 0.92-0.99), 91% (CI 95%: 0.82-0.99) and 73% (CI 95%: 0.66-0.81), respectively.
We found an overall high PPV for both active and non-active cancer across all three types of cancer.
背景/目的：丹麦国家患者登记处（DNPR）提供了独特的流行病学见解，但往往缺乏详细数据。我们提出了一种基于程序的乳腺癌、肺癌和结直肠癌患者癌症状态定义，该定义可应用于行政卫生数据库。由于死亡率和发病率与癌症状态密切相关，因此需要新的癌症状态定义，但大多数研究仅将自癌症诊断以来的持续时间用作严重程度指标。本研究的目的是验证一种新的实用定义。
对来自赫勒夫-根措夫特医院肿瘤科的600例乳腺癌、肺癌和结直肠癌患者的医学期刊进行回顾性研究。我们将活动性癌症定义为癌症诊断后6个月内未进行潜在治愈性手术的情况。其余患者被归类为非活动性癌症。然后将这种二分法与基于所接受治疗和辅助检查（如首次术后对照扫描）的癌症状态评估进行比较。基于此比较，我们计算了活动性和非活动性癌症定义的阳性预测值（PPV）。
计算得出的活动性乳腺癌、肺癌和结直肠癌的PPV分别为87%（95%置信区间：0.74 - 0.99）、91%（95%置信区间：0.87 - 0.96）和82%（95%置信区间：0.73 - 0.91）。非活动性乳腺癌、肺癌和结直肠癌的PPV分别为95%（95%置信区间：0.92 - 0.99）、91%（95%置信区间：0.82 - 0.99）和73%（95%置信区间：0.66 - 0.81）。
我们发现，在所有三种癌症类型中，活动性和非活动性癌症的总体PPV都很高。
