Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan.
Chem Commun (Camb). 2023 May 18;59(41):6211-6214. doi: 10.1039/d3cc00420a.
Iron(II/III)porphyrin/cyclodextrin inclusion complexes serve as hemoprotein models . Here we showed the iron(III)porphyrin complex to be spontaneously reduced to its iron(II) state in mouse circulation. The reduced complex bound endogenous CO from carboxyhemoglobin, which was followed by urinary excretion. The natural reduction system was found to be effective for synthetic heme-model compounds.
铁(II/III)卟啉/环糊精包合物可用作血红素蛋白模型。在这里，我们发现铁(III)卟啉复合物在小鼠循环中可自发还原为其铁(II)状态。还原的复合物从羧基血红蛋白中结合内源性 CO，随后从尿液中排出。天然的还原系统对合成的血红素模型化合物也有效。
