“封端”卟啉化合物中的一氧化碳结合动力学
Carbon monoxide binding kinetics in "capped" porphyrin compounds.
作者信息
Rose E J, Venkatasubramanian P N, Swartz J C, Jones R D, Basolo F, Hoffman B M
出版信息
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5742-5. doi: 10.1073/pnas.79.18.5742.
Abstract
The rate constants for CO binding to the five-coordinate ferrous iron complexes of 5,10,15,20-[pyromellitoyl(tetrakis-o-oxyoxyphenyl)]porphyrin and 5,10,15,20-[pyromellitoyl(tetrakis-o-oxypropoxyphenyl)]porphyrin have been measured and compared with the corresponding rate constants for other hemes and hemoproteins. The second-order rate constant is independent of cap size and is comparable to that of high-affinity state hemoglobin (k5 approximately 4 X 10(6) M-1s-1). Therefore, these capped porphyrins provide no steric hindrance to CO binding. In addition, a kinetic scheme involving an unusual seven-coordinate porphyrin species is described.
摘要
已测定了一氧化碳与5,10,15,20-[均苯四甲酰基（四-o-氧代氧基苯基）]卟啉和5,10,15,20-[均苯四甲酰基（四-o-氧代丙氧基苯基）]卟啉的五配位亚铁配合物结合的速率常数，并与其他血红素和血红蛋白的相应速率常数进行了比较。二级速率常数与帽的大小无关，与高亲和力状态血红蛋白的速率常数相当（k5约为4×10⁶ M⁻¹s⁻¹）。因此，这些带帽卟啉对一氧化碳的结合没有空间位阻。此外，还描述了一个涉及不寻常的七配位卟啉物种的动力学方案。
相似文献
1
Carbon monoxide binding kinetics in "capped" porphyrin compounds.“封端”卟啉化合物中的一氧化碳结合动力学
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5742-5. doi: 10.1073/pnas.79.18.5742.
2
Carbon monoxide binding to iron porphyrins.一氧化碳与铁卟啉的结合。
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6035-9. doi: 10.1073/pnas.76.12.6035.
3
4
Nature of O2 and CO binding to metalloporphyrins and heme proteins.氧气和一氧化碳与金属卟啉及血红蛋白结合的本质。
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3333-7. doi: 10.1073/pnas.73.10.3333.
5
Five-coordinate iron-porphyrin as a model for the active site of hemoproteins. Characterization and coordination properties.
Eur J Biochem. 1976 Dec;71(1):63-76. doi: 10.1111/j.1432-1033.1976.tb11090.x.
6
Iron twin-coronet porphyrins as models of myoglobin and hemoglobin: amphibious electrostatic effects of overhanging hydroxyl groups for successful CO/O2 discrimination.铁双冠卟啉作为肌红蛋白和血红蛋白的模型：突出羟基的两栖静电效应实现CO/O₂的成功辨别
Chemistry. 2003 Feb 17;9(4):862-70. doi: 10.1002/chem.200390096.
7
Resonance Raman detection of Fe-CO stretching and Fe-C-O bending vibrations in sterically hindered carbonmonoxy "strapped hemes". A structural probe of Fe-C-O distortion.空间位阻碳酰基“束缚血红素”中Fe-CO伸缩振动和Fe-C-O弯曲振动的共振拉曼检测。Fe-C-O畸变的结构探针。
Biochemistry. 1983 Sep 13;22(19):4534-40. doi: 10.1021/bi00288a028.
8
Binding of O2 and CO to hemes and hemoproteins.氧气和一氧化碳与血红素及血红蛋白的结合。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3171-5. doi: 10.1073/pnas.77.6.3171.
9
O2 and CO binding properties of artificial hemoproteins formed by complexing iron protoporphyrin IX with human serum albumin mutants.通过铁原卟啉IX与人血清白蛋白突变体络合形成的人工血红蛋白的氧气和一氧化碳结合特性
J Am Chem Soc. 2005 Nov 16;127(45):15933-42. doi: 10.1021/ja054819u.
10
NMR investigation of the electric properties and magnetic states of hemes and hemoproteins : the S = 2 state in ferrous porphyrins.
Biochimie. 1981 Nov-Dec;63(11-12):911-4. doi: 10.1016/s0300-9084(82)80285-x.
引用本文的文献
1
Hinged Carboxylate in the Artificial Distal Pocket of an Iron Porphyrin Enhances CO Electroreduction at Low Overpotential.铁卟啉人工远端口袋中的铰链式羧酸盐可增强低过电位下的CO电还原反应。
Adv Sci (Weinh). 2025 Mar;12(11):e2500482. doi: 10.1002/advs.202500482. Epub 2025 Jan 22.
2
Carbon monoxide signaling and soluble guanylyl cyclase: Facts, myths, and intriguing possibilities.一氧化碳信号转导与可溶性鸟苷酸环化酶：事实、迷思与饶富趣味的可能性。
Biochem Pharmacol. 2022 Jun;200:115041. doi: 10.1016/j.bcp.2022.115041. Epub 2022 Apr 18.
3
How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase.血红素蛋白传感器如何排除氧气？来自细胞色素 c'、念珠藻血红素一氧化氮/氧结合结构域和可溶性鸟苷酸环化酶的经验教训。
Antioxid Redox Signal. 2012 Nov 1;17(9):1246-63. doi: 10.1089/ars.2012.4564. Epub 2012 Apr 10.
4
A "sliding scale rule" for selectivity among NO, CO, and O₂ by heme protein sensors.血红素蛋白传感器对 NO、CO 和 O₂ 选择性的“滑动比例尺规则”。
Biochemistry. 2012 Jan 10;51(1):172-86. doi: 10.1021/bi2015629. Epub 2011 Dec 13.
本文引用的文献
1
Steric control of CO binding in a totally synthetic heme protein model.在一个完全合成的血红素蛋白模型中对 CO 结合的空间位阻控制。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):5919-23. doi: 10.1073/pnas.78.10.5919.
2
The equilibrium between carbon monoxide and sheep haemoglobin at very high percentage saturations.在极高饱和度百分比下一氧化碳与羊血红蛋白之间的平衡。
J Physiol. 1954 Nov 29;126(2):359-83. doi: 10.1113/jphysiol.1954.sp005215.
3
Letter: Enhancement of ligand binding by iron (III) deuteroporphyrin (IX) dimethyl ester via interaction with 1,10-phenanthroline at a site remote from the metal ion.信件：通过在远离金属离子的位点与1,10-菲咯啉相互作用，铁（III）次卟啉（IX）二甲酯增强配体结合。
J Am Chem Soc. 1974 Nov 13;96(23):7378-9. doi: 10.1021/ja00830a048.
4
Carbon monoxide bonding in hemeproteins.
Ann N Y Acad Sci. 1970 Oct 5;174(1):148-53. doi: 10.1111/j.1749-6632.1970.tb49781.x.
5
Use of a fluorescent analogue of 2,3-diphosphoglycerate as a probe of human hemoglobin conformation during carbon monoxide binding.
J Biol Chem. 1971 Sep 25;246(18):5832-5.
6
Properties of hemoglobin A and hemoglobin Zurich (beta63 histidine replaced by arginine): quantitative evaluation of functional abnormalities in hemoglobins.血红蛋白A和苏黎世血红蛋白（β63位组氨酸被精氨酸取代）的特性：血红蛋白功能异常的定量评估
Biochem Biophys Res Commun. 1976 Feb 23;68(4):1379-86. doi: 10.1016/0006-291x(76)90348-x.
7
Conformation and cooperativity in hemoglobin.
Biochemistry. 1975 May 6;14(9):1886-92. doi: 10.1021/bi00680a013.
8
Dissociation of CO from carboxyhemoglobin.一氧化碳从碳氧血红蛋白中的解离。
J Biol Chem. 1976 Jul 25;251(14):4267-72.
Zotero 插件