[霍乱类毒素-类毒素的反应原性和免疫效力。霍乱类毒素-类毒素再接种的可行性、最佳剂量和接种时间的确定]

[Reactogenicity and immunologic effectiveness of cholerogen-anatoxin. Feasibility of revaccination with cholerogen-anatoxin, determination of optimal doses and times for administration].

作者信息

Sumarokov A A, Ivanov N R, Lelikov V L, Dzhaparidze M N, Karaeva L T

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1976(12):85-91.

Abstract

The authors discussed the results of study of the titre of vibration antibodies and antitoxins one, three and five months after the vaccination of adults with an optimal vaccination dose of cholerogen toxoid (24OO BU). Comparison of the immunological information obtained at the above mentioned periods showed the expediency of revaccination three months after the vaccination. Immunogenicity of the three doses of the cholerogen-toxoid tested (1200, 2400, 3600 BU) displayed no statistically significant difference in revaccination. Taking into consideration that the least reactogenic dose was 1200 BU this dose is recommended as the optimal revaccination dose for adults.

摘要

作者讨论了成年人接种最佳剂量霍乱类毒素（2400 BU）后1个月、3个月和5个月时振动抗体和抗毒素滴度的研究结果。对上述时期获得的免疫学信息进行比较表明，接种疫苗3个月后进行再次接种是适宜的。所测试的三剂霍乱类毒素（1200、2400、3600 BU）在再次接种时的免疫原性没有统计学上的显著差异。考虑到反应原性最低的剂量是1200 BU，推荐该剂量作为成年人再次接种的最佳剂量。