Kuznetsov G P, Lebedev P A
Kardiologiia. 1986 Mar;26(3):49-52.
The hypotensive effect of triampur was studied in 39 patients with first- and second-stage essential hypertension, as was the pharmacokinetics of triamterin, the main constituent of triampur. A relationship is demonstrated between the curve area, blood triamterin peak, clearance and cumulative excretion, on the one hand, and the hypotensive effect, on the other. Triamterin pharmacokinetic studies may be used for the screening of hypertensive patients as potential candidates for triampur treatment. Alongside other causes, low blood concentrations of the drug in the course of treatment may be associated with its low efficiency.
研究了氨苯蝶啶复方制剂（triampur）对39例一期和二期原发性高血压患者的降压作用，以及该复方制剂的主要成分氨苯蝶啶的药代动力学。结果表明，一方面，曲线下面积、血氨苯蝶啶峰值、清除率和累积排泄量与另一方面的降压效果之间存在关联。氨苯蝶啶药代动力学研究可用于筛选作为氨苯蝶啶复方制剂治疗潜在候选者的高血压患者。除其他原因外，治疗过程中药物血浓度低可能与其疗效低有关。
