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[科林法缓释片单药治疗以及与可多纳和曲安普明联合治疗高血压患者的药代动力学研究]

[A pharmacokinetic study of korinfar-retard in monotherapy and in combination with cordanum and triampur in patients with arterial hypertension].

作者信息

Kukes V G, Ignat'ev V I, Kurapov A P, Pavlov S S, Rumiantsev A S, Chil'tsov V V

出版信息

Eksp Klin Farmakol. 1994 Nov-Dec;57(6):50-2.

PMID:7756964
Abstract

The long-acting corinfar formulation, corinfar-retard tablets, 20 mg (AWD, Germany), was studied for pharmacokinetics in single and course use in 40 patients with arterial hypertension, as well as for its effects of cordanum and triampur. Patients' plasma corinfar was measured by high performance liquid chromatography. There were no changes in the pharmacokinetics of the agent when it was used in its course use. Cordanum and triampur was demonstrated to have no effects on the pharmacokinetics of corinfar during their application.

摘要

对长效科利法尔制剂(科利法尔缓释片,20毫克,德国AWD公司生产)在40例动脉高血压患者单次及疗程使用时的药代动力学进行了研究,并研究了其与可多拿和曲安西龙的相互作用。采用高效液相色谱法测定患者血浆中的科利法尔含量。该药物在疗程使用时药代动力学无变化。研究表明,可多拿和曲安西龙在应用过程中对科利法尔的药代动力学无影响。

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