Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.
Aging Clin Exp Res. 2023 Jun;35(6):1363-1367. doi: 10.1007/s40520-023-02419-6. Epub 2023 May 2.
Aim of the study was to explore frailty and quality of the relationship with the caregiver in a cohort of older patients with transthyretin cardiac amyloidosis (ATTR-CA). Sixty-eight consecutive ATTR-CA patients were recruited and assessed for frailty, depressive symptoms, quality of the relationship in terms of social support, or conflict toward caregivers, New York Heart Association Class (NYHA), and National Amyloid Center score (NAC Score) for grading disease severity. Results showed that 10% of patients were frail. Depressive symptoms were present in 46% of patients. Regression analyses showed that both mFI and depression were associated with worse perception of social support, and that mFI and NAC score were associated with higher levels of conflict perceived in the caregivers' relationship. Overall, the mFI score was associated with worse perceived social support and caregiver relationship quality. Tertiary care heart failure clinics should actively support the patient-caregiver relationship to improve quality of life.
研究目的在于探讨脆弱性及其与照料者关系的质量在转甲状腺素蛋白心脏淀粉样变（ATTR-CA）老年患者队列中的作用。招募了 68 名连续的ATTR-CA 患者，并评估了他们的脆弱性、抑郁症状、社会支持方面的关系质量或与照料者的冲突、纽约心脏协会（NYHA）分级和用于分级疾病严重程度的国家淀粉样中心评分（NAC 评分）。结果显示，10%的患者身体脆弱，46%的患者存在抑郁症状。回归分析表明，mFI 和抑郁均与社会支持感知较差相关，而 mFI 和 NAC 评分与感知到的照料者关系中的冲突程度较高相关。总体而言，mFI 评分与较差的社会支持和照料者关系质量相关。三级心脏衰竭诊所应积极支持患者-照料者关系，以提高生活质量。
