Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune Maharashtra, 411038, India.
Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India.
J Pharm Pharmacol. 2023 Jun 5;75(6):719-745. doi: 10.1093/jpp/rgac092.
Urolithiasis has been a major health concern for centuries, primarily owing to the limited treatment options in the physician's armamentarium. However, various studies have underscored a lesser incidence of urolithiasis in cohorts predominantly consuming fruits and vegetables. This article aims to review various dietary plants, medicinal herbs and phytochemicals in the prevention and management of urolithiasis.
To provide context and evidence, relevant publications were identified on Google Scholar, PubMed and Science-Direct using keywords such as urolithiasis, nephrolithiasis, urolithiasis, renal stones, phytochemicals and dietary plants.
Growing bodies of evidence suggest the incorporation of plant-based foods, medicinal and herbal supplements, and crude drugs containing phytochemicals into the staple diet of people. The anti-urolithiatic activity of these plant bioactives can be attributed to their antioxidant, antispasmodic, diuretic, and inhibitory effect on the crystallization, nucleation and crystal aggregation effects. These mechanisms would help alleviate the events and symptoms that aid in the development and progression of renal calculi. In addition, it will also avoid the exacerbation of secondary disorders like inflammation and injury, which can initiate a vicious circle in turn worsening the disease progression.
In conclusion, the results presented in the review demonstrate the promising role of various dietary plants, medicinal and herbal supplements, and phytochemicals in preventing and managing the precipitation of uroliths. However, more conclusive and cogent evidence from preclinical and clinical studies is required to substantiate their safety, efficacy and toxicity profiles in humans.
结石病一直是几个世纪以来的一个主要健康关注点，主要是由于医生治疗方案中有限的治疗选择。然而，各种研究都强调，在主要食用水果和蔬菜的人群中，结石病的发病率较低。本文旨在综述各种用于预防和治疗结石病的饮食植物、药草和植物化学物质。
为了提供背景和证据，我们在 Google Scholar、PubMed 和 Science-Direct 上使用了关键词，如结石病、肾结石、结石病、肾结石、植物化学物质和饮食植物，检索了相关出版物。
越来越多的证据表明，将植物性食物、药用和草药补充剂以及含有植物化学物质的粗药纳入人们的主食中。这些植物生物活性物质的抗结石作用可以归因于它们的抗氧化、抗痉挛、利尿和抑制结晶、成核和晶体聚集的作用。这些机制有助于减轻有助于肾结石发展和进展的事件和症状。此外，它还可以避免炎症和损伤等继发性疾病的恶化，这反过来又会使疾病恶化。
总之，综述中呈现的结果表明，各种饮食植物、药用和草药补充剂以及植物化学物质在预防和治疗结石沉淀方面具有有希望的作用。然而，需要更多来自临床前和临床研究的更具结论性和说服力的证据，以证实它们在人类中的安全性、疗效和毒性特征。
