Department of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China.
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China; and.
Retina. 2023 Aug 1;43(8):1386-1392. doi: 10.1097/IAE.0000000000003824.
To determine the effect of different durations of topical anesthesia on intravitreal injection (IVI) pain.
This was a double-blinded, randomized, comparative study . Three hundred and twelve sequential eyes undergoing IVI were randomized to one of six groups according to the duration of topical anesthesia (from 1 to 30 minutes, one group for every 5-minute range, Groups 1-6). Topical anesthesia before IVI was standardized. Patients graded their pain using the visual analog scale and the Wong-Baker FACES scale at 15 minutes after the procedure.
The pain scores among the six groups were significantly different for the visual analog scale ( P = 0.013) and Wong-Baker FACES scale ( P = 0.024). The mean pain scores for Group 4 were 1.97 ± 1.04 (visual analog scale) and 2.02 ± 1.08 (Wong-Baker FACES scale) and were significantly lower than those of Group 1, 2, 5, or 6.
The duration of topical anesthesia significantly correlated with IVI pain. Preoperative 0.5% proparacaine hydrochloride drops were most effective in relieving IVI pain 11 to 20 minutes after topical administration.
确定不同时长的局部麻醉对玻璃体腔内注射（IVI）疼痛的影响。
这是一项双盲、随机、对照研究。312 只连续进行 IVI 的眼睛根据局部麻醉时长（1 至 30 分钟，每组 5 分钟）随机分为六组（1-6 组）。IVI 前的局部麻醉标准化。患者在术后 15 分钟使用视觉模拟量表和 Wong-Baker FACES 量表评估疼痛程度。
六组的视觉模拟量表（P=0.013）和 Wong-Baker FACES 量表（P=0.024）疼痛评分差异有统计学意义。第 4 组的平均疼痛评分为 1.97±1.04（视觉模拟量表）和 2.02±1.08（Wong-Baker FACES 量表），显著低于第 1、2、5 或 6 组。
局部麻醉的持续时间与 IVI 疼痛显著相关。术前滴用 0.5%丙美卡因眼液 11-20 分钟可最有效地缓解 IVI 疼痛。
