Khezri Mohammad Rafi, Ghasemnejad-Berenji Morteza
Urmia University of Medical Sciences, Faculty of Pharmacy, Urmia, Iran.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
NPJ Aging. 2023 May 2;9(1):9. doi: 10.1038/s41514-023-00104-6.
Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia worldwide. Different pathologic changes have been introduced to be involved in its progression. Although amyloid-β (Aβ) deposition and tau hyperphosphorylation and aggregation are mainly considered the main characterizations of AD, several other processes are involved. In recent years, several other changes, including alterations in gut microbiota proportion and circadian rhythms, have been noticed due to their role in AD progression. However, the exact mechanism indicating the association between circadian rhythms and gut microbiota abundance has not been investigated yet. This paper aims to review the role of gut microbiota and circadian rhythm in AD pathophysiology and introduces a hypothesis to explain their association.
阿尔茨海默病（AD）是全球最常见的神经退行性疾病，也是痴呆症的主要病因。不同的病理变化已被证明与该病的进展有关。尽管淀粉样β蛋白（Aβ）沉积、tau蛋白过度磷酸化和聚集主要被认为是AD的主要特征，但还涉及其他几个过程。近年来，由于肠道微生物群比例和昼夜节律的变化在AD进展中的作用，人们已经注意到了其他一些变化。然而，昼夜节律与肠道微生物群丰度之间关联的确切机制尚未得到研究。本文旨在综述肠道微生物群和昼夜节律在AD病理生理学中的作用，并提出一个假说来解释它们之间的关联。
