Crowley James J, Cappi Carolina, Ochoa-Panaifo Marcos E, Frederick Renee M, Kook Minjee, Wiese Andrew D, Rancourt Diana, Atkinson Elizabeth G, Giusti-Rodriguez Paola, Anderberg Jacey L, Abramowitz Jonathan S, Adorno Victor R, Aguirre Cinthia, Alves Gustavo S, Alves Gilberto S, Ancalade NaEshia, Espinosa Alejandro A Arellano, Arnold Paul D, Ayton Daphne M, Barbosa Izabela G, Castano Laura Marcela Barón, Barrera Cynthia N, Prieto María Belén, Berardo María Celeste, Berrones Dayan, Best John R, Bigdeli Tim B, Burton Christie L, Callahan Jennifer L, Carneiro Maria Cecília B, Cepeda Sandra L, Chazelle Evelyn, Chire Jessica M, Munoz Macarena Churruca, Quiroz Pamela Claisse, Cobite Journa, Comer Jonathan S, Costa Daniel L, Crosbie Jennifer, Cruz Victor O, Dager Guillermo, Daza Luisa F, de la Rosa-Gómez Anabel, Del Río Daniela, Delage Fernanda Z, Dreher Carolina B, Fay Lucila, Fazio Tomas, Ferrão Ygor A, Ferreira Gabriela M, Figueroa Edith G, Fontenelle Leonardo F, Forero Diego A, Fragoso Daniele Th, Gadad Bharathi S, Garrison Sheldon R, González Andres, Gonzalez Laura D, González Marco A, Gonzalez-Barrios Polaris, Goodman Wayne, Guintivano Jerry, Guttfreund Daniel G, Guzick Andrew G, Halvorsen Matthew W, Hovey Joseph D, Janssen-Aguilar Reinhard, Jensen Matias, Reynolds Alexandra Z Jimenez, Lujambio Joali Alexandra Juárez, Khalfe Nasim, Knutsen Madison A, Lack Caleb, Lanzagorta Nuria, Lima Monicke O, Longhurst Melanie O, Martinez David A Lozada, Luna Elba S, Marques Andrea H, Martinez Molly, de Los Angeles Matos Maria, Maye Caitlyn E, McGuire Joseph F, Menezes Gabriela, Minaya Charlene, Miño Tomás, Mithani Sara M, de Oca Circe Montes, Morales-Rivero Alonso, Moreira-de-Oliveira Maria E, Morris Olivia J, Muñoz Sandra I, Naqqash Zainab, Bracho Ambar A Núñez, Bracho Belinda E Núñez, Rojas Maria Corina Ochoa, Castaman Luis A Olavarria, Ortega Iliana, Patel Darpan I, Patrick Ainsley K, Mino Mariel Paz Y, Orellana Jose L Perales, Stumpf Bárbara Perdigão, Peregrina Tamara, Duarte Tania Pérez, Piacsek Kelly L, Placencia Maritza, Quarantini Lucas C, Quarantini-Alvim Yana, Ramos Renato T, Ramos Iaroslava C, Ramos Vanessa R, Ramsey Kesley A, Ray Elise V, Richter Margaret A, Riemann Bradley C, Rivas Juan C, Rosario Maria C, Ruggero Camilo J, Ruiz-Chow Angel A, Ruiz-Velasco Alejandra, Sampaio Aline S, Saraiva Leonardo C, Schachar Russell J, Schneider Sophie C, Schweissing Ethan J, Seligman Laura D, Shavitt Roseli G, Soileau Keaton J, Stewart S Evelyn, Storch Shaina B, Strouphauer Emily R, Timpano Kiara R, Treviño-de la Garza Beatriz, Vargas-Medrano Javier, Vásquez María I, Martinez Guadalupe Vidal, Weinzimmer Saira A, Yanez Mauricio A, Zai Gwyneth, Zapata-Restrepo Lina M, Zappa Luz M, Zepeda-Burgos Raquel M, Zoghbi Anthony W, Miguel Euripedes C, Rodriguez Carolyn I, Mallen Mayra C Martinez, Moya Pablo R, Borda Tania, Moyano María Beatriz, Mattheisen Manuel, Pereira Stacey, Lázaro-Muñoz Gabriel, Martinez-Gonzalez Karen G, Pato Michele T, Nicolini Humberto, Storch Eric A
University of North Carolina at Chapel Hill, Department of Genetics, Chapel Hill, North Carolina, United States of America.
University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, North Carolina, United States of America.
medRxiv. 2023 Feb 26:2023.02.23.23286373. doi: 10.1101/2023.02.23.23286373.
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.
强迫症(OCD)是一种使人衰弱的精神疾病。在全球范围内,其患病率约为2%,病因大多不明。确定导致强迫症的生物学因素将阐明其潜在机制,并可能有助于改善治疗效果。对强迫症的基因组研究开始揭示长期以来寻找的风险位点,但目前正在分析的病例中超过95%是欧洲血统的同质样本。如果不加以解决,这种以欧洲为中心的偏差将导致强迫症基因组研究结果对欧洲血统个体比对其他血统个体更准确,从而在基因组学未来的潜在应用中造成健康差异。在本研究方案论文中,我们描述了拉丁美洲强迫症基因组跨血统倡议(LATINO,www.latinostudy.org)。LATINO是一个由来自拉丁美洲、美国和加拿大的研究人员组成的新网络,他们已开始以文化敏感且符合伦理的方式,从5000例具有丰富表型的拉丁美洲血统强迫症病例中收集DNA和临床数据。在这个项目中,我们将利用跨血统基因组分析来加速强迫症风险位点的识别,精细定位假定的因果变异,并提高多基因风险评分在不同人群中的性能。我们还将利用丰富的临床数据来研究治疗反应的遗传学、生物学上合理的强迫症亚型以及症状维度。此外,LATINO将通过与拉丁美洲研究人员合作开发并提供的各种培训,帮助阐明强迫症在不同文化中的临床表现多样性。我们相信这项研究将推进全球心理健康发现与公平这一重要目标。