Durussel J J, Claperon N, Dufaux J, Quemada D, Rossignol P
J Pharmacol Methods. 1986 Jun;15(3):201-11. doi: 10.1016/0160-5402(86)90050-1.
We propose a constant cephalic blood perfusion method especially suitable to the rat. Cerebrovascular blood pressure is artificially regulated by an extracorporeal circuit with a perfusion pump and a Starling valve. A hemorrheological evaluation allows one to demonstrate an extracorporeal circuit that shows a growing pathological evolution, which can be purposely accelerated by iterative ischemic episodes. This method can be used (as shown by some examples) as a model for cerebrovascular failure or to study deleterious effects of the extracorporeal circuit.
