Chertkov J L, Drize N J, Gurevitch O A, Udalov G A
Leuk Res. 1986;10(6):659-63. doi: 10.1016/0145-2126(86)90269-9.
Long-term haemopoiesis in bone marrow culture is sustained by the progeny of haemopoietic progenitor cells (HPC), which differ from CFUs by very low sensitivity to repeated hydroxyurea (HU) injections. The transit time of a haemopoietic clone from HPC to cells proliferating in culture is 6-7 weeks. The results suggest that the stem cell continuum is an expansion type compartment, members of which gradually lose their proliferative potential during differentiation.
骨髓培养中的长期造血由造血祖细胞（HPC）的后代维持，HPC与集落形成单位（CFU）不同，对反复注射羟基脲（HU）的敏感性非常低。一个造血克隆从HPC到在培养中增殖的细胞的过渡时间为6至7周。结果表明，干细胞连续体是一个扩增型区室，其成员在分化过程中逐渐失去增殖潜能。
