College of Food Science and Nutritional Engineering, China Agricultural University, National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry, National Engineering Research Center for Fruit and Vegetable Processing, Beijing 100083, China.
Beijing Industrial Technology Research Institute Ltd, Beijing, China.
Food Funct. 2023 May 22;14(10):4866-4880. doi: 10.1039/d3fo00294b.
Millet protein has gained much attention for its beneficial effects in mitigating metabolic diseases. However, most individuals pass through a prediabetic phase before developing full-blown diabetes, and whether millet protein has hypoglycemic effects on prediabetic mice remains unclear. In the present study, heat-treated foxtail millet protein (HMP) supplementation significantly decreased fasting blood glucose and serum insulin levels, alleviated insulin resistance, and improved impaired glucose tolerance in prediabetic mice. In addition, HMP altered the intestinal flora composition, as evidenced by the reduction in the abundance of and and the increase in the content of , , and . Moreover, HMP supplementation dramatically regulated the levels of serum metabolites (, LysoPCs, 11,14,17-eicosatrienoic acid, and sphingosine) and related metabolic pathways, such as sphingolipid metabolism and pantothenate and CoA biosynthesis. In conclusion, the improvement of gut microbiota and serum metabolic profiles was related to the hypoglycemic potential of HMP in prediabetes.
小米蛋白因其在缓解代谢疾病方面的有益作用而受到广泛关注。然而，大多数个体在发展为典型糖尿病之前都会经历糖尿病前期阶段，小米蛋白对糖尿病前期小鼠是否具有降血糖作用尚不清楚。在本研究中，热处理的黍蛋白（HMP）补充剂可显著降低空腹血糖和血清胰岛素水平，减轻胰岛素抵抗，并改善糖尿病前期小鼠的葡萄糖耐量受损。此外，HMP 改变了肠道菌群组成，表现为 和 的丰度降低， 和 的含量增加。此外，HMP 补充剂还显著调节了血清代谢物（溶血磷脂、LysoPCs、11,14,17-二十碳三烯酸和神经鞘氨醇）和相关代谢途径（鞘脂代谢和泛酸和辅酶 A 生物合成）的水平。总之，肠道微生物群和血清代谢谱的改善与 HMP 在糖尿病前期的降血糖潜力有关。
