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两例吉娃娃犬兄妹的眼全身性肺囊虫病。

Oculosystemic pneumocystosis in 2 sibling Chihuahuas.

机构信息

Department of Medicine and Epidemiology, University of California-Davis, Davis, California, USA.

Department of Pathology, Microbiology & Immunology, University of California-Davis, Davis, California, USA.

出版信息

J Vet Intern Med. 2023 May-Jun;37(3):1179-1185. doi: 10.1111/jvim.16729. Epub 2023 May 3.

DOI:10.1111/jvim.16729
PMID:37134072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10229366/
Abstract

Sibling female and male Chihuahuas were evaluated for a 9-month history of tachypnea that failed to respond to fenbendazole, doxycycline, amoxicillin-clavulanate, and prednisone. Physical examination identified tachypnea, hyperpnea, and harsh bronchovesicular lung sounds. Fundic examination disclosed diffuse chorioretinitis, manifested as multifocal chorioretinal granulomas in the female dog and occasional chorioretinal scars in the male dog. Thoracic radiographs indicated moderate to severe interstitial to broncho-interstitial infiltrates in both dogs. Serum and urine antigen and antibody testing in the female dog failed to identify infectious agents, but cytologic assessment of hepatic lymph node, liver, and splenic aspirates identified Pneumocystis trophozoites. Infection was confirmed in both dogs by 28S rRNA PCR sequencing from multiple tissue samples. The female dog responded well to trimethoprim-sulfamethoxazole, but the male dog was euthanized because of liver failure, presumably related to antimicrobial treatment.

摘要

两只雌性和雄性吉娃娃犬因呼吸急促就诊，病史 9 个月，曾接受芬苯达唑、多西环素、阿莫西林克拉维酸和泼尼松治疗，但未见改善。体格检查发现呼吸急促、过度通气和粗湿啰音。眼底检查显示弥漫性脉络膜炎，表现为雌性犬的多发性脉络膜视网膜肉芽肿和雄性犬偶尔的脉络膜视网膜瘢痕。胸部 X 线片显示两只犬均存在中重度间质性至支气管间质性浸润。雌性犬的血清和尿液抗原及抗体检测未能识别出病原体，但对肝门淋巴结、肝脏和脾脏抽吸物的细胞学评估发现了卡氏肺孢子虫滋养体。通过对多个组织样本的 28S rRNA PCR 测序，在两只犬中均证实了感染。雌性犬对甲氧苄啶-磺胺甲噁唑反应良好，但因肝功能衰竭，雄性犬被安乐死，可能与抗菌药物治疗有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/e38e6066c05e/JVIM-37-1179-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/468e95d2b849/JVIM-37-1179-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/7345176e2305/JVIM-37-1179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/5563ffc46c13/JVIM-37-1179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/e38e6066c05e/JVIM-37-1179-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/998bcb6c4d23/JVIM-37-1179-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/feb3e2c95332/JVIM-37-1179-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/407a36e9dd4a/JVIM-37-1179-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/c7b1dfbd3334/JVIM-37-1179-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/468e95d2b849/JVIM-37-1179-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/7345176e2305/JVIM-37-1179-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/5563ffc46c13/JVIM-37-1179-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d294/10229366/e38e6066c05e/JVIM-37-1179-g004.jpg

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