Lista A, Abarca J, Ramos C, Daniels A J
Life Sci. 1986 Jun 9;38(23):2121-7. doi: 10.1016/0024-3205(86)90211-0.
Injection of manganese into the rat corpus striatum causes a rapid fall in the biopterin and dopamine (DA) content ipsilateral to the lesion. Two weeks after the lesion both biopterin and DA are partially recovered. Controls, injected with saline or magnesium, do not show alterations in their DA or cofactor levels. It is proposed that the fall in DA levels results from a rapid displacement of the amine from its storage sites by manganese followed by a decrease in the rate of DA synthesis causes by the drop in cofactor levels.
向大鼠纹状体注射锰会导致损伤同侧的生物蝶呤和多巴胺（DA）含量迅速下降。损伤两周后，生物蝶呤和多巴胺均部分恢复。注射生理盐水或镁的对照组，其多巴胺或辅因子水平未显示出变化。有人提出，多巴胺水平的下降是由于锰使胺从其储存部位迅速移位，随后由于辅因子水平下降导致多巴胺合成速率降低所致。
