Stanley P, Mijch A
Med J Aust. 1986 May 26;144(11):603-5. doi: 10.5694/j.1326-5377.1986.tb112322.x.
The clinical features and laboratory findings of 78 cases of methyldopa fever are reported. This drug reaction masqueraded as a variety of acute infectious diseases including septicaemia, meningitis, hepatitis and gastroenteritis, occurred within five weeks of starting the drug and appeared to be unrelated to its dosage. Eosinophilia and skin rashes were conspicuous by their absence. In the majority of patients, symptoms were relieved within 48 hours of the withdrawal of the drug. Sixty-one per cent of patients had biochemical evidence of liver damage but jaundice was uncommon. This pattern of mild hepatotoxicity in patients with early febrile reactions to methyldopa contrasts with the later more serious viral hepatitis-like illness due to the drug.
报告了78例甲基多巴热的临床特征和实验室检查结果。这种药物反应伪装成多种急性传染病，包括败血症、脑膜炎、肝炎和肠胃炎，在开始用药后五周内出现，且似乎与其剂量无关。嗜酸性粒细胞增多和皮疹明显缺乏。大多数患者在停药后48小时内症状缓解。61%的患者有肝损伤的生化证据，但黄疸并不常见。甲基多巴早期发热反应患者的这种轻度肝毒性模式与该药物后期更严重的病毒性肝炎样疾病形成对比。
