Department of Medical Imaging, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China.
Blood Purification Center, The Sixth People's Hospital of Qingdao, Qingdao, China.
Cytokine. 2023 Jul;167:156211. doi: 10.1016/j.cyto.2023.156211. Epub 2023 May 1.
Musclin is a recently found myokine involved in the process of glucose metabolism. The purpose of the present investigation is to evaluate the relationship between serum musclin levels and diabetic nephropathy (DN).
The current investigation included 175 (T2DM) cases and 62 controls. T2DM patients were divided into three subgroups: normoalbuminuria (DN0), microalbuminuria (DN1), and macroalbuminuria (DN2) on the basis of the values of urine albumin to creatinine ratio (ACR).
T2DM group displayed higher serum musclin than the controls. Serum musclin were remarkably elevated in DN2 subgroup compared with DN0 and DN1 subgroups. In addition, elevated serum musclin was observed in DN1 subgroup than in the DN0 subgroup. Serum musclin was correlated with an increased risk of having T2DM and DN using a logistic regression model. Linear regression analysis showed that serum musclin was negatively related with gender, and positively related with body mass index, systolic blood pressure, blood urea nitrogen, creatinine, and ACR.
Serum musclin increases with the progressed stages of DN. Serum musclin is associated with renal function parameters and ACR.
肌联蛋白是一种新发现的肌因子，参与葡萄糖代谢过程。本研究旨在评估血清肌联蛋白水平与糖尿病肾病（DN）的关系。
本研究纳入 175 例（T2DM）患者和 62 例对照者。根据尿白蛋白与肌酐比值（ACR），T2DM 患者分为三组：正常白蛋白尿（DN0）、微量白蛋白尿（DN1）和大量白蛋白尿（DN2）。
T2DM 组血清肌联蛋白水平高于对照组。DN2 亚组血清肌联蛋白明显高于 DN0 和 DN1 亚组。此外，DN1 亚组血清肌联蛋白高于 DN0 亚组。使用 logistic 回归模型显示，血清肌联蛋白与 T2DM 和 DN 的发生风险增加相关。线性回归分析显示，血清肌联蛋白与性别呈负相关，与体重指数、收缩压、血尿素氮、肌酐和 ACR 呈正相关。
血清肌联蛋白随 DN 进展阶段而增加。血清肌联蛋白与肾功能参数和 ACR 相关。
