Department of Blood Transfusion, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Department of Endocrinology, The Third People's Hospital of Qingdao, Qingdao, China.
Diabetes Res Clin Pract. 2020 Nov;169:108443. doi: 10.1016/j.diabres.2020.108443. Epub 2020 Sep 15.
Meteorin-like (Metrnl), a secreted myokine, is induced in white adipose tissue during cold exposure and in muscle after exercise. The present investigation aims to determine the hypothesis that serum Metrnl concentrations are correlated with diabetic nephropathy (DN).
The investigation was performed in a population of 221 patients with type 2 diabetes mellitus (T2DM) and 74 healthy subjects. T2DM patients were divided into three groups: normoalbuminuria (n = 100), microalbuminuria (n = 86), and macroalbuminuria (n = 35) subgroups based on urine albumin to creatinine ratio (ACR).
All the three T2DM subgroups showed lower serum Metrnl concentrations compared with the controls. Serum Metrnl concentrations were significantly decreased in T2DM patients with macroalbuminuria group than in the other T2DM subgroups. In addition, T2DM patients with microalbuminuria group had decreased serum Metrnl concentrations compared with those with normoalbuminuria; however, the difference was not significant. Logistic regression analysis demonstrated a correlation between serum Metrnl and a decreased risk of T2DM and DN (OR: 0.954, 95% CI: 0.935-0.973, P < 0.001 and OR: 0.981, 95% CI: 0.971-0.997, P = 0.014, respectively). Simply linear regression analysis indicated a negative association between serum Metrnl and duration of disease, body mass index (BMI), HbA1c, blood urea nitrogen, creatinine, uricacid, ACR, and angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers treatment. BMI, HbA1c, and ACR were still correlated with the serum Metrnl after a multiple linear regression analysis.
Serum Metrnl concentrations are inversely correlated with renal function and DN.
类流星体（Metrnl）是一种分泌的肌肉因子，在冷暴露时在白色脂肪组织中诱导产生，在运动后在肌肉中诱导产生。本研究旨在验证血清 Metrnl 浓度与糖尿病肾病（DN）相关的假说。
该研究在 221 例 2 型糖尿病（T2DM）患者和 74 例健康受试者的人群中进行。根据尿白蛋白与肌酐比值（ACR），T2DM 患者分为三组：正常白蛋白尿组（n=100）、微量白蛋白尿组（n=86）和大量白蛋白尿组（n=35）。
所有 T2DM 亚组的血清 Metrnl 浓度均低于对照组。与其他 T2DM 亚组相比，大量白蛋白尿组 T2DM 患者的血清 Metrnl 浓度显著降低。此外，微量白蛋白尿组 T2DM 患者的血清 Metrnl 浓度低于正常白蛋白尿组，但差异无统计学意义。Logistic 回归分析表明，血清 Metrnl 与 T2DM 和 DN 的风险降低呈正相关（OR：0.954，95%CI：0.935-0.973，P<0.001 和 OR：0.981，95%CI：0.971-0.997，P=0.014）。简单线性回归分析表明，血清 Metrnl 与疾病持续时间、体重指数（BMI）、HbA1c、血尿素氮、肌酐、尿酸、ACR 和血管紧张素转换酶抑制剂/血管紧张素 II 受体阻滞剂治疗呈负相关。在多元线性回归分析后，BMI、HbA1c 和 ACR 仍与血清 Metrnl 相关。
血清 Metrnl 浓度与肾功能和 DN 呈负相关。
