Ji Xing, Hu Xinhua, Xu Taotao, Yang Wanlei
Department of Pharmacology, School of Medicine, Hangzhou City University, Hangzhou, China.
Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China.
Front Endocrinol (Lausanne). 2025 Jun 11;16:1600218. doi: 10.3389/fendo.2025.1600218. eCollection 2025.
The musculoskeletal system is not only closely linked anatomically, but muscle-derived myokines also play a crucial role in bone development and metabolism beyond the effects of mechanical force. Myokines are essential in muscle-bone crosstalk, significantly influencing bone remodeling and metabolism. In the context of diabetes, including both type 1 (T1DM) and type 2 (T2DM), changes in myokine expression have a substantial impact on bone metabolism, leading to an increased risk of osteoporosis. This review provides a comprehensive examination of the roles of key myokines in regulating osteoblast lineage cells and osteoclast activity. We highlight how different myokines can either promote or inhibit bone formation and resorption and discuss their altered expression levels under diabetic conditions. A deeper understanding of the multifaceted roles of myokines may open new avenues for treating osteoporosis, particularly in diabetic patients.
肌肉骨骼系统不仅在解剖学上紧密相连，而且肌肉衍生的肌动蛋白在骨发育和代谢中也起着关键作用，其作用超出了机械力的影响。肌动蛋白在肌肉与骨骼的相互作用中至关重要，对骨重塑和代谢有显著影响。在包括1型糖尿病（T1DM）和2型糖尿病（T2DM）在内的糖尿病背景下，肌动蛋白表达的变化对骨代谢有重大影响，导致骨质疏松风险增加。本综述全面探讨了关键肌动蛋白在调节成骨细胞谱系细胞和破骨细胞活性中的作用。我们强调了不同肌动蛋白如何促进或抑制骨形成和吸收，并讨论了它们在糖尿病条件下的表达水平变化。对肌动蛋白多方面作用的更深入理解可能为治疗骨质疏松症开辟新途径，尤其是在糖尿病患者中。
