Department of Neonatal Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Front Immunol. 2023 Apr 17;14:1127375. doi: 10.3389/fimmu.2023.1127375. eCollection 2023.
Neuroimmune pathways are important part of the regulation of inflammatory response. Nerve cells regulate the functions of various immune cells through neurotransmitters, and then participate in the inflammatory immune response. Hirschsprung's disease (HD) is a congenital abnormal development of intestinal neurons, and Hirschsprung-associated enterocolitis (HAEC) is a common complication, which seriously affects the quality of life and even endangers the lives of children. Neuroimmune regulation mediates the occurrence and development of enteritis, which is an important mechanism. However, there is a lack of review on the role of Neuroimmune regulation in enterocolitis associated with Hirschsprung's disease. Therefore, this paper summarizes the characteristics of the interaction between intestinal nerve cells and immune cells, reviews the neuroimmune regulation mechanism of Hirschsprung's disease associated enterocolitis (HAEC), and looks forward to the potential clinical application value.
神经免疫途径是炎症反应调节的重要组成部分。神经细胞通过神经递质调节各种免疫细胞的功能，进而参与炎症免疫反应。先天性巨结肠（HD）是一种肠神经元的先天性异常发育，而与之相关的结肠炎（HAEC）是一种常见的并发症，严重影响患儿的生活质量，甚至危及生命。神经免疫调节介导肠炎的发生发展，是一个重要的机制。然而，目前缺乏对神经免疫调节在先天性巨结肠相关肠炎中作用的综述。因此，本文总结了肠神经细胞与免疫细胞相互作用的特点，综述了先天性巨结肠相关肠炎的神经免疫调节机制，并展望了其潜在的临床应用价值。
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