Liu Yu-Dong, Tang Fang, Li Xiao-Li, Liu Ya-Fei, Zhang Peng, Yang Chun-Lin, Du Tong, Li Heng, Wang Cong-Cong, Liu Ying, Yang Bing, Duan Rui-Sheng
Department of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China.
Center for Big Data Research in Health and Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China.
Front Neurol. 2023 Apr 17;14:1125842. doi: 10.3389/fneur.2023.1125842. eCollection 2023.
A certain number of myasthenia gravis (MG) patients clinically had type 2 diabetes mellitus (T2DM) prior to MG onset, which suggests that the onset of MG may correlate with the history of T2DM. This study aimed to examine the correlation between MG and T2DM.
In a single-center, retrospective, 1:5 matched case-control study, all 118 hospitalized patients with a diagnosis of MG from 8 August 2014 to 22 January 2019 were enrolled. In total, four datasets with different sources of the control group were retrieved from the electronic medical records (EMRs). Data were collected at the individual level. A conditional logistic regression analysis was used to test the risk of MG associated with T2DM.
The risk of MG was significantly associated with T2DM, and there were notable differences by sex and age. Whether compared to the general population, general hospitalized patients without autoimmune diseases (AIDs), or patients with other AIDs except MG, women aged over 50 years with T2DM had an increased risk of MG. The mean onset age of diabetic MG patients was more than that of the non-diabetic MG patients.
This study demonstrates that T2DM is strongly associated with the subsequent risk of MG and varies significantly by sex and age. It reveals that diabetic MG may be a unique subtype that is different from the conventional MG subgroup classification. More clinical and immunological features of diabetic MG patients need to be explored in further studies.
一定数量的重症肌无力（MG）患者在MG发病前临床上已患有2型糖尿病（T2DM），这表明MG的发病可能与T2DM病史相关。本研究旨在探讨MG与T2DM之间的相关性。
在一项单中心、回顾性、1:5匹配的病例对照研究中，纳入了2014年8月8日至2019年1月22日期间所有118例住院诊断为MG的患者。总共从电子病历（EMR）中检索了四个不同来源的对照组数据集。数据在个体层面收集。采用条件逻辑回归分析来检验与T2DM相关的MG风险。
MG风险与T2DM显著相关，且在性别和年龄方面存在显著差异。与普通人群、无自身免疫性疾病（AIDs）的普通住院患者或除MG外的其他AIDs患者相比，50岁以上患有T2DM的女性患MG的风险增加。糖尿病性MG患者的平均发病年龄高于非糖尿病性MG患者。
本研究表明T2DM与随后发生MG的风险密切相关，且在性别和年龄上有显著差异。它揭示了糖尿病性MG可能是一种独特的亚型，不同于传统的MG亚组分类。糖尿病性MG患者更多的临床和免疫学特征需要在进一步研究中探索。
