Takeuchi I K, Takeuchi Y K
Neurobehav Toxicol Teratol. 1986 Mar-Apr;8(2):143-50.
When pregnant rats were X-irradiated at a dose of 100 R on gestational day 9.5, a considerable number of postnatally-viable hydrocephalic offspring resulted, all of which were accompanied with bilateral micro- or anophthalmia. Histological studies revealed that the cerebral aqueduct of the congenital hydrocephalic brain was severely stenosed, and the subcommissural organ was reduced in size and displaced at some distance from the anterior end of the cerebral aqueduct. From embryological studies, it was considered that the maldevelopment of the subcommissural organ in the X-irradiated fetus might cause a reduction in the amount of its secretions which function as a cushion preventing complete closure of the cerebral aqueduct during fetal life, resulting in stenosis of the cerebral aqueduct.
当怀孕大鼠在妊娠第9.5天接受100伦琴的X射线照射时，产生了相当数量出生后存活的脑积水后代，所有这些后代都伴有双侧小眼或无眼。组织学研究表明，先天性脑积水大脑的中脑导水管严重狭窄，连合下器官体积减小并从导水管前端移位一段距离。从胚胎学研究来看，人们认为受X射线照射胎儿的连合下器官发育不良可能导致其分泌物量减少，而这些分泌物在胎儿期起到缓冲作用以防止中脑导水管完全闭合，从而导致中脑导水管狭窄。
