Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Genomic and Proteomic Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
World J Biol Psychiatry. 2023 Nov;24(9):822-828. doi: 10.1080/15622975.2023.2209876. Epub 2023 May 15.
Major depression (MD) may be associated with inflammation and immunity. PD-1 (programmed death-1), PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2) are among the inhibitory immune mediators on the PD-1 pathway. However, previous data regarding the association between MD and PD-1 pathway were still scarce; therefore, we investigated the association of PD-1 pathway with MD.
During a period of 2 years, patients with MD and healthy controls were recruited from a medical centre in this study. The diagnosis of MD was established according to the DSM-5 criteria. The severity of MD was assessed with 17-item Hamilton Depression Rating Scale. PD-1, PD-L1 and PD-L2 were detected in peripheral blood from MD patients after 4 weeks of treatment with antidepressant drugs.
A total of 54 patients with MD and 38 healthy controls were recruited. According to the analyses, there is a significantly higher PD-L2 level in MD than in healthy controls and lower PD-1 level after age and BMI adjustment. Besides, moderately positive correlation between HAM-D scores and PD-L2 level was found.
It was found that PD-1 pathway might play an important role in MD. We need a large sample to prove these results in the future.
重度抑郁症（MD）可能与炎症和免疫有关。PD-1（程序性死亡受体 1）、PD-L1（程序性死亡配体 1）和 PD-L2（程序性死亡配体 2）是 PD-1 通路中的抑制性免疫调节剂。然而，之前关于 MD 与 PD-1 通路之间关联的数据仍然很少；因此，我们研究了 PD-1 通路与 MD 的关联。
在 2 年期间，从本研究中的一家医疗中心招募了 MD 患者和健康对照者。根据 DSM-5 标准诊断 MD。使用 17 项汉密尔顿抑郁评定量表评估 MD 的严重程度。在抗抑郁药物治疗 4 周后，从 MD 患者的外周血中检测 PD-1、PD-L1 和 PD-L2。
共招募了 54 名 MD 患者和 38 名健康对照者。根据分析，在年龄和 BMI 调整后，MD 患者的 PD-L2 水平明显高于健康对照组，PD-1 水平较低。此外，HAM-D 评分与 PD-L2 水平之间存在中度正相关。
研究发现 PD-1 通路可能在 MD 中发挥重要作用。我们需要更大的样本量来证明这些结果。
